How Depression Symptoms Change With Medication, Group Therapy, or Both
Studies antidepressant medication, cognitive-behavioral group therapy, or both in adults with major depression.
Plain-language title generated from the registry record
Registry title: Dynamic Networks in Depression Treatment: Mechanisms of Change in Pharmacological, Psychological and Combined Treatment of Depression
Key facts
- Where
- Frankfurt and Marburg, GermanySee the 3 sites
- Phase
- Phase 4
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT07488910, who can take part
Where in Germany
- Clinical Psychology and PsychotherapyFrankfurt, GermanyNo longer taking part
- Department of Psychiatry, Psychosomatics and PsychotherapyFrankfurt, GermanyNo longer taking part
- Department of Psychiatry and PsychotherapyMarburg, GermanyNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Goethe University
- Trial code
- NCT07488910
- Record updated
- 23 March 2026
- Original description
This study investigates how antidepressant pharmacotherapy, cognitive-behavioral therapy, or their combination modulate the temporal dynamics and connectivity of depressive symptom networks. Using intensive longitudinal ecological momentary assessment data, the trial examines treatment-specific changes in symptom interactions.Read full original descriptionShow less
Veränderungen Dynamischer Symptom-Netzwerke Unter Pharmakologischer, Psychotherapeutischer Und Kombinierter Behandlung Bei Depression (DYNDET)
This study investigates how antidepressant pharmacotherapy, cognitive-behavioral therapy, or their combination modulate the temporal dynamics and connectivity of depressive symptom networks. Using intensive longitudinal ecological momentary assessment data, the trial examines treatment-specific changes in symptom interactions.
By applying network-based analytic approaches, the study aims to elucidate differential and potentially complementary mechanisms of change across treatment modalities. Findings may contribute to more informed and individualized treatment strategies for major depressive disorder.
Inclusion: Depressive disorder (mild to moderate symptom severity); 18-65 years; must own a smartphone with internet access.
Exclusion: concurrent psychotherapeutic treatment; bipolar disorder,; substance use disorder; severe medical or neurological illness; conditions that may interfere with fMRI; severe depressive episode; acute suicidality,; psychotic depression; insufficient german language skills.