Arthrosamid vs. Steroid for the Management of Knee Osteoarthritis
Key facts
- Who runs it
- Cappagh National Orthopaedic Hospital
- Where
- Dublin, IrelandSee the site
- Trial code
- Status
- Recruiting
- Phase
- Phase 4
- People taking part
- 200 people, planned
- Started
- 29 Jan 2026
- Expected to end
- Sept 2027
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Arthrosamid® 2.5% iPAAG injectable implant
- Steroid Drug
- Record updated
- 28 April 2026
Who can take part
- Age
- 18 years to 100 years
- Sex
- Women and men
- Healthy volunteers
- Can take part
The registry criteria, word for word
Show all 12 criteriaShow less
Who can take part
- Adults
- Symptomatic single side knee pain
- Patients with diagnosis of knee osteoarthritis radiographic Kellgren and Lawrence system OA grade II-III-IV on x ray or MRI
Who cannot take part
- Intra-articular injection of corticosteroids during the previous 3 months, intra-articular injection of other drugs, such as hyaluronic acid over the previous 1 year
- Inflammatory conditions,
- Cancer,
- acute infection,
- Uncontrolled diabetes mellitus,
- Joint diseases in the knee, such as rheumatoid arthritis or gout, history of knee surgery with metallic implant
- Contraindications for intra-articular injection, such as thrombocytopenia, coagulopathy, articular infection of knee, impairment of immunity
- pregnancy and breastfeeding
- If patient has undergone knee arthroscopy in past 6 months
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 100 years old?
Where in Ireland
- Cappagh National Orthopaedic HospitalDublin, IrelandContact: SEAN TEE LIM, MDTaking people
About the trial
What the trial wants to find out
This study will be a randomised control trial of the use of intra-articular Arthrosamid® a novel intraarticular hydrogel vs. standard of care (steroid and local anaesthetic) for the non-operative management of knee osteoarthritis.
The 2 groups in the trial
- ArthrosamidTreatment being tested
Patient with knee osteoarthritis Arthrosamid Injection. This is a non-biodegradable 2.5% iPAAG injectable implant. It is given once.
Treatment: Arthrosamid® 2.5% iPAAG injectable implant
- SteroidExisting treatment, for comparison
Patient with knee osteoarthritis Steroid arm is as follow with one injection containing: Dexamethasone 8mg and methylprednisolone 80mg and bupivacaine 0.25% 5 mls.
Treatment: Steroid Drug
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- A Randomised Control Trial of the Use of an Intraarticular Hydrogel Arthrosamid® vs. Steroid for the Non-operative Management of Knee Osteoarthritis
- Fit questions
- Built from NCT07489521, who can take part
- Record updated
- 28 April 2026