Two Pacemaker Methods for Heart Failure With a Conduction Block
Compares two pacemaker pacing methods in adults with heart failure and bundle branch block.
Plain-language title generated from the registry record
Registry title: Conduction System Pacing vs. Biventricular Pacing for Cardiac Resynchronization Therapy
Key facts
- Where
- Gothenburg, SwedenSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 99 years old?
Source: NCT07492979, who can take part
Where in Sweden
- Sahlgrenska University HospitalGothenburg, SwedenNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Copenhagen University Hospital, Rigshospitalet
- Trial code
- NCT07492979
- Record updated
- 28 July 2026
- Original description
The NORDIC-CSP trial is an investigator-initiated, blinded, nordic RCT aimed at evaluating whether using direct pacing of the HIS bundle (HIS)-pacing or left bundle branch (LBB) pacing is superior to conventional biventricular pacing in reducing the incidence of the composite endpoint of death and non-planned HF hospitalization. The study will be conducted in the 4 CRT-centres in Denmark and 6-8 centres from countries Sweden, Norway and Finland.Read full original descriptionShow less
Nordic-CSP - a Randomized Nordic Study - Is Conduction System Pacing Superior Compared to Conventional BIV-CRT in Reducing the Death or Heart Failure-related Hospitalization in Patients With Heart Failure and Bundle Branch Block?
The NORDIC-CSP trial is an investigator-initiated, blinded, nordic RCT aimed at evaluating whether using direct pacing of the HIS bundle (HIS)-pacing or left bundle branch (LBB) pacing is superior to conventional biventricular pacing in reducing the incidence of the composite endpoint of death and non-planned HF hospitalization. The study will be conducted in the 4 CRT-centres in Denmark and 6-8 centres from countries Sweden, Norway and Finland.
Inclusion: ≥18 years of age,; LVEF ≤ 35%,; NYHA Class II-IV (IV only outpatients),; optimized in medical treatment (OMT); AND one of the following:; . LBBB according to AHA/ACC/HRS Scientific Statement from 2009 and ≥130ms or; LBBB-like intraventricular conduction delay (IVCD) > 150ms or RV paced QRS and indication for upgrade to CRT (> 40% RV pacing) OR; ≥18 years of age,; LVEF ≤ 40 %; pacing indicated by AV-block and, thus, expected large percentage of ventricular pacing.
Exclusion: treatment with a cardiac implantable electronic device (CIED) is contraindicated; recent acute myocardial infarction (AMI); Patients are excluded with regards to the MRI sub study if eGFR > 35 ml/min, in case or contrast allergy or certain metal implants; life expectancy <2 years, patients in hemodialysis; coronary artery bypass graft (CABG) (<3 months).