Two Pacemaker Methods for Heart Failure With a Conduction Block
Compares two pacemaker pacing methods in adults with heart failure and bundle branch block.
Plain-language title generated from the registry record
Registry title: Conduction System Pacing vs. Biventricular Pacing for Cardiac Resynchronization Therapy
Key facts
- Where
- Gothenburg, SwedenSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with heart failure and a weak heart pump who need a pacemaker-type device (cardiac resynchronization therapy), or who need pacing for AV-block.
- Age
- 18 Years to 99 Years
- Sex
- All sexes can join.
- Disease stage
- Heart failure with LVEF ≤ 35% and NYHA Class II-IV (IV only outpatients), plus left bundle branch block (LBBB) of ≥130ms, LBBB-like conduction delay > 150ms, or RV paced QRS with an indication to upgrade to CRT (> 40% RV pacing). Another way in: LVEF ≤ 40% with pacing needed for AV-block and a large share of ventricular pacing expected.
- Earlier treatment
- Optimized medical treatment (OMT) is required.
Main reasons for not taking part
- Recent acute myocardial infarction (AMI)
- Coronary artery bypass graft (CABG) in the last 3 months
- Life expectancy under 2 years or being on hemodialysis
- A cardiac implantable electronic device (CIED) is contraindicated
- For the MRI sub study: eGFR > 35 ml/min, contrast allergy or certain metal implants
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 99 years old?
Source: NCT07492979, who can take part
Where in Sweden
- Sahlgrenska University HospitalGothenburg, SwedenNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Copenhagen University Hospital, Rigshospitalet
- Trial code
- NCT07492979
- Record updated
- 28 July 2026
- Original description
The NORDIC-CSP trial is an investigator-initiated, blinded, nordic RCT aimed at evaluating whether using direct pacing of the HIS bundle (HIS)-pacing or left bundle branch (LBB) pacing is superior to conventional biventricular pacing in reducing the incidence of the composite endpoint of death and non-planned HF hospitalization. The study will be conducted in the 4 CRT-centres in Denmark and 6-8 centres from countries Sweden, Norway and Finland.Read full original descriptionShow less
Nordic-CSP - a Randomized Nordic Study - Is Conduction System Pacing Superior Compared to Conventional BIV-CRT in Reducing the Death or Heart Failure-related Hospitalization in Patients With Heart Failure and Bundle Branch Block?
The NORDIC-CSP trial is an investigator-initiated, blinded, nordic RCT aimed at evaluating whether using direct pacing of the HIS bundle (HIS)-pacing or left bundle branch (LBB) pacing is superior to conventional biventricular pacing in reducing the incidence of the composite endpoint of death and non-planned HF hospitalization. The study will be conducted in the 4 CRT-centres in Denmark and 6-8 centres from countries Sweden, Norway and Finland.
Inclusion: ≥18 years of age,; LVEF ≤ 35%,; NYHA Class II-IV (IV only outpatients),; optimized in medical treatment (OMT); AND one of the following:; . LBBB according to AHA/ACC/HRS Scientific Statement from 2009 and ≥130ms or; LBBB-like intraventricular conduction delay (IVCD) > 150ms or RV paced QRS and indication for upgrade to CRT (> 40% RV pacing) OR; ≥18 years of age,; LVEF ≤ 40 %; pacing indicated by AV-block and, thus, expected large percentage of ventricular pacing.
Exclusion: treatment with a cardiac implantable electronic device (CIED) is contraindicated; recent acute myocardial infarction (AMI); Patients are excluded with regards to the MRI sub study if eGFR > 35 ml/min, in case or contrast allergy or certain metal implants; life expectancy <2 years, patients in hemodialysis; coronary artery bypass graft (CABG) (<3 months).