Supervised exercise for veterans with heart failure and preserved ejection fraction
Looks at monitored exercise during cardiac rehabilitation in veterans with heart failure.
Plain-language title generated from the registry record
Registry title: Precision Rehabilitation for Veterans With (HFpEF)
Key facts
- Where
- Columbia, United StatesSee the site
Where in United States
- Columbia VA Health Care SystemColumbia, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Columbia VA Health Care System
- Trial code
- NCT07493915
- Record updated
- 25 March 2026
- Original description
This study is being completed because there is conflicting information regarding the value of monitored exercise in patients with heart failure with preserved ejection fraction (HFpEF). The purpose of this study is to collect baseline information necessary for researchers to pursue a larger study evaluating how monitored exercise performed during cardiac rehabilitation may improve heart health and the amount of oxygen delivered to the tissues during exercise. Researchers must first examine whether the facility is capable of supporting such a study and whether in a modest number of patients, there is no clear detrimental effect to exercise. Rather, there may be an important improvement that has been underestimated to date.Read full original descriptionShow less
Precision Rehabilitation for Veterans With Heart Failure With Preserved Ejection Fraction (HFpEF)
This study is being completed because there is conflicting information regarding the value of monitored exercise in patients with heart failure with preserved ejection fraction (HFpEF). The purpose of this study is to collect baseline information necessary for researchers to pursue a larger study evaluating how monitored exercise performed during cardiac rehabilitation may improve heart health and the amount of oxygen delivered to the tissues during exercise. Researchers must first examine whether the facility is capable of supporting such a study and whether in a modest number of patients, there is no clear detrimental effect to exercise. Rather, there may be an important improvement that has been underestimated to date.
Participation will require a time commitment for performing exercise 3 times per week for 12 weeks in addition to having a small amount of blood drawn twice. There will also be a specialized form of a stress test (cardiopulmonary exercise test; "CPET") with ultrasound imaging of the heart (echocardiography) completed twice.
Inclusion: New York Heart Association Class II or III HF symptoms; History of hypertension; EF≥50%; LVH confirmed by echocardiography, Cardiac CT, or Cardiac MR; Diastolic dysfunction which must include ≥2 of the following:; Average E/e'>14; Septal e'<7 cm/s or Lateral e' <10 cm/s; TR velocity> 2.8 m/s; LA computed volume index >34 mL/M2; PCWP or LVEDP>15; Ability to participate in an exercise program as determined by a research, cardiology, or primary care provider.
Exclusion: Acute ST segment elevation myocardial infarction (STEMI); Significant valvular or other non-coronary heart disease; Any non-cardiac disease or condition that could influence myocardial function (e.g., collagen-vascular disease, history of cardiotoxic cancer chemotherapy, amyloid); Current accelerating angina, unstable angina, angina at rest, or NSTEMI within 3 months; Chronic pulmonary disease requiring home oxygen or steroid therapy; Ejection Fraction < 50%; Anemia defined as Hgb < 11.0 g/dl in males, 10 g/dl in females; Significant non-CV organ disease: Chronic hepatic or renal disease (eGFR < 25 mL/min/1.73m2); Absence of LVH; LV Dilation (LV end diastolic volume indexed to BSA > 75 ml/m2); Any Segmental wall motion abnormality; Inability to provide informed consent; Inability to perform exercise.