Studying the Biology of Autism Using Lab-Grown Organoids From Patient Cells
Studies lab-grown organoids made from cells of people with autism spectrum disorder.
Plain-language title generated from the registry record
Registry title: Exploring the Physiological Mechanisms of Austism Through Organoids
Key facts
- Where
- Paris, FranceSee the site
Where in France
- Robert Debre hospitalParis, FranceNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Assistance Publique - Hôpitaux de Paris
- Trial code
- NCT07494331
- Record updated
- 27 March 2026
- Original description
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder affecting approximately 1% of the population, characterized by difficulties with social interaction and communication. Studies have identified more than 200 genes linked to ASD, particularly those involved in chromatin remodeling and synaptic neuronal connectivity (CHD8, SCN2A, NLGN3-4X, SHANK1-3). The goal of the project is to decipher the biological mechanisms underlying ASD in order to develop therapeutic strategies, using innovative preclinical models such as organoids.Read full original descriptionShow less
Exploring the Physiologicla Mechainisms of Austism Through Organoids Derived Differentiated Cells of Individuals With Autism
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder affecting approximately 1% of the population, characterized by difficulties with social interaction and communication. Studies have identified more than 200 genes linked to ASD, particularly those involved in chromatin remodeling and synaptic neuronal connectivity (CHD8, SCN2A, NLGN3-4X, SHANK1-3). The goal of the project is to decipher the biological mechanisms underlying ASD in order to develop therapeutic strategies, using innovative preclinical models such as organoids.
Inclusion: A child diagnosed with an autism spectrum disorder in accordance with clinical practice guidelines; A sibling without an autism spectrum disorder (SRS < 65); Biological parents; Children and parents must be enrolled in a social security program, Universal Health Coverage (CMU), or an equivalent program.
Exclusion: Uncontrolled (unstabilized) medical condition (including psychiatric conditions) that precludes participation in the study; Sibling with an SRS score > 65 at screening or under 2 years old; Refusal to undergo a blood test.