Joint Endoprostheses Can Succesfully Treat Disabling Osteoarthritis. However, Infection is an Important Cause of Failure. Adequate Diagnostics Remains Challenging. Combining Advanced Imaging With Next-generation Sequencing of Samples Obtained Endoscopically Should Aid in Mapping and Characterizing.
Key facts
- Who runs it
- University Hospital, Ghent
- Where
- Belgium1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Active, not recruiting
- People taking part
- 174 people enrolled
- Started
- 18 Sept 2018
- Expected to end
- 31 Dec 2027
- Type of study
- Interventional
- Treatments tested
- Comprehensive Diagnostic Work-up for Suspected Chronic Periprosthetic Joint Infection
- Record updated
- 27 March 2026
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 8 criteriaShow less
Who can take part
- Adult patients
- Presence of a joint prosthesis
- Clinical suspicion of chronic periprosthetic joint infection
- Scheduled for diagnostic arthroscopy and/or open surgical evaluation as part of standard care
- Written informed consent provided
Who cannot take part
- Acute postoperative infections
- Inability or refusal to provide informed consent
- Insufficient clinical data or samples for diagnostic evaluation
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
This prospective observational diagnostic study aims to improve the accuracy and timeliness of diagnosing chronic periprosthetic joint infection (PJI). By systematically integrating clinical history, serological markers, synovial fluid analysis, microbiological cultures, next-generation sequencing (NGS), histopathology, minimally invasive arthroscopic sampling, open surgical sampling, sonication, and nuclear imaging, the study evaluates which diagnostic factors and combinations thereof most reliably identify the presence, extent, location, and causative microorganism(s) of PJI. The ultimate objective is to provide evidence-based recommendations to refine and optimize the current unified PJI diagnostic definition.
The group in the trial
- Single arm study with observational and diagnostic puprosesOther group
Participants receive diagnostic investigations that are clinically indicated as part of routine care for suspected chronic periprosthetic joint infection. No additional diagnostic or therapeutic procedures are mandated by the study protocol.
Treatment: Comprehensive Diagnostic Work-up for Suspected Chronic Periprosthetic Joint Infection
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- The Unhappy Patient With a Painful Joint Endoprosthesis: Mapping a Periprosthetic Joint Infection and Analysis of Themicrobiome/Biofilm
- Record updated
- 27 March 2026