NCT07500324Recruiting
Proteomic Biomarker Identification in Age-Related Macular Degeneration, Diabetic Retinopathy and Retinal Detachment
Identification And Validation Of Biomarkers In Ophthalmological Diseases (Age-Related Macular Degeneration, Diabetic Retinopathy And Retinal Detachment) Through Clinical Proteomic Approaches
Source: ClinicalTrials.gov · Last updated 2 Jun 2026
Brief summary (registry, in English)
This prospective interventional translational study aims to identify and validate protein biomarkers associated with major ophthalmological diseases, including age-related macular degeneration, diabetic retinopathy (DR), and retinal detachment (RD). A total of approximately 260 participants (cases and controls) will be enrolled at a single center. Biological samples, including peripheral blood, tears, aqueous humor, vitreous humor, and subretinal fluid, will be collected during routine clinical and surgical procedures. Advanced clinical proteomics approaches will be applied to characterize molecular signatures associated with disease onset, progression, and response to treatment. The study seeks to improve the understanding of disease pathophysiology and support the development of novel diagnostic and prognostic biomarkers in ophthalmology.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 260 (estimated)
- First submitted
- 24 Mar 2026
- Start date
- 24 Jan 2024
- Primary completion date
- 31 Jan 2027
- Lead sponsor
- Fondazione G.B. Bietti, IRCCS
- Diseases
- Macular degeneration, Diabetic eye disease
- NCT number
- NCT07500324
What you commit to
- Study type: Interventional
- Planned participants: 260
- From 24 Jan 2024 to the primary completion date, 31 Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Presence of infectious ocular diseases
Age
- Age \< 18 years
Other
- Alterations in the electrophoretic profile of gamma globulins
Who the study is looking for
- Age ≥ 18 years
- Ability to understand the study procedures and provide written informed consent
- Willingness and ability to comply with study procedures and visits
- For case subjects:
- Patients with age-related macular degeneration (intermediate or advanced, including geographic atrophy or neovascular AMD)
- Patients with diabetic retinopathy (non-proliferative or proliferative, with or without diabetic macular edema)
- Patients undergoing surgery for primary or recurrent retinal detachment
- For control subjects:
- Patients scheduled for cataract surgery with no documented retinal diseases (e.g., AMD, diabetic retinopathy, retinal vascular occlusions, or retinal epithelial disorders)
- Outpatients with no documented retinal diseases
- For retinal detachment subgroup: patients undergoing macular surgery (e.g., macular pucker or macular hole) or cataract surgery with attached retina
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| IRCCS Fondazione G.B. Bietti Coordinator of this site? Confirm its status | Roma | Italy | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.