Looking for protein markers in macular degeneration, diabetic retinopathy and retinal detachment
Studies proteins in eye and blood samples from adults with these eye diseases.
Plain-language title generated from the registry record
Registry title: Proteomic Biomarker Identification in Age-Related Macular Degeneration, Diabetic Retinopathy and Retinal Detachment
Key facts
- Where
- Roma, ItalySee the site
Where in Italy
- IRCCS Fondazione G.B. BiettiRoma, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Fondazione G.B. Bietti, IRCCS
- Trial code
- NCT07500324
- Record updated
- 2 June 2026
- Original description
This prospective interventional translational study aims to identify and validate protein biomarkers associated with major ophthalmological diseases, including age-related macular degeneration, diabetic retinopathy (DR), and retinal detachment (RD). A total of approximately 260 participants (cases and controls) will be enrolled at a single center.Read full original descriptionShow less
Identification And Validation Of Biomarkers In Ophthalmological Diseases (Age-Related Macular Degeneration, Diabetic Retinopathy And Retinal Detachment) Through Clinical Proteomic Approaches
This prospective interventional translational study aims to identify and validate protein biomarkers associated with major ophthalmological diseases, including age-related macular degeneration, diabetic retinopathy (DR), and retinal detachment (RD). A total of approximately 260 participants (cases and controls) will be enrolled at a single center.
Biological samples, including peripheral blood, tears, aqueous humor, vitreous humor, and subretinal fluid, will be collected during routine clinical and surgical procedures. Advanced clinical proteomics approaches will be applied to characterize molecular signatures associated with disease onset, progression, and response to treatment.
The study seeks to improve the understanding of disease pathophysiology and support the development of novel diagnostic and prognostic biomarkers in ophthalmology.
Inclusion: Age ≥ 18 years; Ability to understand the study procedures and provide written informed consent; Willingness and ability to comply with study procedures and visits; For case subjects:; Patients with age-related macular degeneration (intermediate or advanced, including geographic atrophy or neovascular AMD); Patients with diabetic retinopathy (non-proliferative or proliferative, with or without diabetic macular edema); Patients undergoing surgery for primary or recurrent retinal detachment; For control subjects:; Patients scheduled for cataract surgery with no documented retinal diseases (e.g., AMD, diabetic retinopathy, retinal vascular occlusions, or retinal epithelial disorders); Outpatients with no documented retinal diseases; For retinal detachment subgroup: patients undergoing macular surgery (e.g., macular pucker or macular hole) or cataract surgery with attached retina.
Exclusion: Presence of infectious ocular diseases; Age < 18 years; Alterations in the electrophoretic profile of gamma globulins.