AI-Guided Online Cognitive-Behavioral Therapy for Major Depressive Disorder
Tests online cognitive-behavioral therapy against a sham treatment in adults with depression.
Plain-language title generated from the registry record
Registry title: Integrating Digital Phenotypes and AI-Driven Cognitive-Behavioral Therapy: Advancing Precision Medicine in Depression Through Digital Medicine
Key facts
- Where
- Taichung, TaiwanSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT07500714, who can take part
Where in Taiwan
- Mind-Body Interface Research Center (MBI Lab & Care)Taichung, TaiwanTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- National Science and Technology Council, Taiwan
- Trial code
- NCT07500714
- Record updated
- 30 March 2026
- Original description
This project aims to integrate digital phenotyping and AI-driven iCBT into a comprehensive platform for MDD diagnosis and treatment in Taiwan. The study will explore dynamic, real-time behavioral and physiological markers to refine diagnostic classifications and optimize personalized therapeutic strategies.Read full original descriptionShow less
Integrating Digital Phenotypes and AI-Driven Cognitive-Behavioral Therapy: Advancing Precision Medicine in Depression Through Digital Medicine
This project aims to integrate digital phenotyping and AI-driven iCBT into a comprehensive platform for MDD diagnosis and treatment in Taiwan. The study will explore dynamic, real-time behavioral and physiological markers to refine diagnostic classifications and optimize personalized therapeutic strategies.
Inclusion: (1) Aged 18-75 years; Diagnosis of major depressive disorder disorder (Based on Diagnostic Statistical Manual 5); 21-item Hamilton Depression Scale (HAMD21)>17; No changes in current psychiatric treatment for depression (e.g., no treatment, antidepressant medication, psychotherapy, or non-invasive brain stimulation) within the past four weeks, and; Full competency to understand the study details and provide written informed consent.
Exclusion: Psychotic disorders, bipolar affective disorder, a substance use disorders in the past 6 months, active suicidal or homicidal ideation (per assessment or HAMD>3); Unstable or active medical illness; Scores of 5 ( Markedly ill), 6,(Severely ill), and 7 (Among the most extremely ill) according to the Clinical Global Impression Scale-Severity (CGI-S).