Exercise Training and Muscle Health in Older Adults With Multiple Sclerosis
Tests an exercise program in older adults with multiple sclerosis.
Plain-language title generated from the registry record
Registry title: Skeletal Muscle Aging and Responsiveness in Aged People With MS
Key facts
- Where
- Oklahoma City, United StatesSee the site
Where in United States
- Oklahoma Medical Research FoundationOklahoma City, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Oklahoma Medical Research Foundation
- Trial code
- NCT07500727
- Record updated
- 30 March 2026
- Original description
The purposes of this study are to: 1) compare baseline muscle and cardiovascular health in older individuals (>60 years old) diagnosed with MS to age-matched people without MS, 2) determine muscle and whole body changes to an exercise training program, 3) determine if the muscle in a more affected leg in individuals diagnosed with MS is different from the muscle of a less affected leg, and 4) if or how individuals diagnosed with MS adapt differently than age-matched people without MS to exercise training. Participation in this study will average 1.5 hours per visit, 3 visits per week, for approximately 4 months.Read full original descriptionShow less
Skeletal Muscle Aging and Responsiveness in Aged People With MS
The purposes of this study are to: 1) compare baseline muscle and cardiovascular health in older individuals (>60 years old) diagnosed with MS to age-matched people without MS, 2) determine muscle and whole body changes to an exercise training program, 3) determine if the muscle in a more affected leg in individuals diagnosed with MS is different from the muscle of a less affected leg, and 4) if or how individuals diagnosed with MS adapt differently than age-matched people without MS to exercise training. Participation in this study will average 1.5 hours per visit, 3 visits per week, for approximately 4 months.
Inclusion: 1. Male or female aged 60 or above 2. Free of unmanaged chronic diseases other than multiple sclerosis 3. No structured exercise program (2 or more bouts/wk) within previous 6 months 4. Cognitively capable of providing informed consent 5. Must meet EDSS score between 2 to 5.5 during screening.
Exclusion: 1. Neuromuscular or musculoskeletal disorder, other than multiple sclerosis, that would limit the ability to perform the exercise and/or testing bouts; Cardiopulmonary disorders or reduced breathing capacity; Metabolic diseases including markers of liver disease (ALT > 52 U/dl) and type 2 diabetes (HbA1C ≥ 6.5, fasting blood glucose ≥ 126 mg/dl); Taking any dose of metformin; Any other disease or disorder that would influence exercise response (e.g., chronic kidney disease, Alzheimer's, current cancer diagnosis or within 2 yr remission, cerebrovascular); History of Chemotherapy within 5 years; Unchangeable anticoagulant (Coumadin, Pradaxa, etc.) use. To be determined by clinical staff; Insulin sensitizing/blood glucose lowering (e.g., metformin) or metabolic (GLP1 agonists) drugs; High dose statin (40 mg and above); Have a non-correctable visual impairment; Score less than 29 on the Symbol Digit Test; Received Botox for spasticity within the prior 3 months of study participation; Cannot have any adjustments to Baclofen during study participation; Unable to commit to ~4 months required to complete the study; Lidocaine allergy; Tobacco use; Excessive alcohol consumption (3 drinks/d or 7 drinks/wk for females; 4 drinks/day or drinks/wk for males); BMI greater than 35.0 kg/m2.