Measuring Walking Problems in Children and Young People After Sarcoma Surgery
Studies how children treated for sarcoma walk after leg surgery, compared with healthy children.
Key facts
- Who runs it
- St. Jude Children's Research Hospital
- Where
- Memphis, United StatesSee the site
- Trial code
- Registry title
- Deep Phenotyping Gait Deficits in Orthopedic Manifestations of Pediatric Cancer Patients
- Status
- Recruiting
- People taking part
- 300 people, planned
- Started
- 16 Jun 2026
- Expected to end
- Jan 2032
- Type of study
- Observational, 2 groups
- Treatments tested
- Lab based 3D Gait Assessment
- Wearable Inertial Sensors (In Lab and Remote)
- Functional Testing & Patient Reported Outcomes
- Remote Wearable Sensor Assessment
- Record updated
- 18 June 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for children and young people aged 5 to 20 who need orthopedic surgery for a lower limb bone sarcoma, a soft tissue sarcoma, or steroid-induced avascular necrosis. Healthy children of the same age also take part as a comparison group.
- Age
- 5 to 20 years old
- Sex
- All sexes
- Disease stage
- Patients need orthopedic surgery for lower limb bone sarcoma, soft tissue sarcoma, or steroid-induced avascular necrosis, with further treatment or follow-up care at St. Jude.
Main reasons for not taking part
- Pre-existing genetic or congenital disorder affecting gait, for example cerebral palsy
- Cannot follow age-appropriate instructions during the gait assessment
- Radiation-induced avascular necrosis
- Healthy group: health conditions affecting walking or mobility
- Cannot or will not give written informed consent
The registry criteria, word for word
Show all 15 criteriaShow less
Who can take part
- Cases:
- Participant requiring orthopedic surgery due to a diagnosis of lower limb bone sarcoma, soft tissue sarcoma, or steroid-induced avascular necrosis (Appendix III) and will receive further additional treatment and/or follow-up care at St. Jude
- Participant is between the ages of ≥5 and ≤20 years old at the time of enrollment; Controls:
- Participant is between the ages of ≥5 and ≤20 years old at the time of enrollment
- Participant (or their parent/legal guardian) considers themself healthy for their age
- Participant (or their parent/legal guardian) reports being able to participate in normal daily activities of life with respect to their age
Who cannot take part
- Individuals diagnosed with radiation-induced avascular necrosis; Controls:
- Individuals with pre-existing genetic/congenital disorders affecting gait will be excluded e.g., cerebral palsy
- Individuals who self-report health conditions affecting gait and mobility
- Individuals who have the following conditions: diabetes mellitus due to impaired circulation, sensation and strength, malignant cancers, demyelinating inflammatory and degenerative neurological conditions, pregnancy, obesity (BMI >40 kg/m2), severe cardiac or pulmonary disease affecting performance of daily activities, history of major surgery affecting gait and mobility, infections or inflammatory arthropathies, severe mobility impairment necessitating dependence on mobility aids for all ambulation
- Individuals who are unable to follow age-appropriate instructions during the gait assessment
- Individuals who are unable to follow age-appropriate instructions during the gait assessment
- Cases:
- Inability or unwillingness of research participant or legal guardian/representative to give written informed consent
- Individual or legal guardian/representative is unable or unwilling to give written informed consent
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 5 and 20 years old?
Where in United States
- St. Jude Children's Research HospitalMemphis, United StatesContact: Joshua Burns, PhDTaking people
About the trial
What the trial wants to find out
The goal of DEEPGAIT study is to determine how serious walking problems are for pediatric cancer patients who have had orthopedic surgery, how they change over time, and what can be done to help. Healthy participants without cancer will also be included in this study in order to better understand the difference in walking problems between the 2 groups.
Read full original descriptionShow less
DEEPGAIT is a long term study that uses advanced tools-including 3D motion capture, muscle sensors, force plates, and wearable devices-to take a detailed look at how these patients move. Their results are compared to healthy children of the same age and sex.
PRIMARY OBJECTIVES
* Characterize gait deficits in pediatric cancer patients 1 year following orthopedic surgery for lower limb bone sarcoma, soft tissue sarcoma, or steroid-induced avascular necrosis. * Identify personal, disease, treatment and environment risk factors for gait deficits in pediatric cancer patients 1 year following orthopedic surgery for lower limb bone sarcoma, soft tissue sarcoma, or steroid-induced avascular necrosis.
SECONDARY OBJECTIVES
* Build a library of broadly representative normative reference values to generate age- and sex-matched z-scores to quantify frequency, severity and progression of gait deficits among pediatric cancer patients in relation to healthy controls. * Characterize the changes of gait parameters in pediatric cancer patients with or without gait deficits 1 year after orthopedic surgery for lower limb bone sarcoma, soft tissue sarcoma, or steroid-induced avascular necrosis, up to 5 years after surgery. * Identify personal, disease, treatment and environment risk factors for trajectories of gait deficits in pediatric cancer patients with or without gait deficits 1 year after orthopedic surgery for lower limb bone sarcoma, soft tissue sarcoma, or steroid-induced avascular necrosis, up to 5 years after surgery.
The 2 groups in the trial
- Pediatric Cancer Surgery Cohort (Cases)
This group includes children and teens (ages 5-20 years) who need surgery on a leg joint or bone because of a cancer related condition. They take part in the study several times: before surgery, and then 1, 2, and 5 years after surgery. They also do a week of at home monitoring after the 1 year visit.
Treatment: Lab based 3D Gait Assessment, Wearable Inertial Sensors (In Lab and Remote), Functional Testing & Patient Reported Outcomes, and Remote Wearable Sensor Assessment
- Healthy Control Cohort
This group includes healthy children and teens (ages 5-20 years) who are matched by age and sex to participants in the surgery group. They take part in the study once, around the same time the surgery participant reaches their 1 year visit.
Treatment: Lab based 3D Gait Assessment, Wearable Inertial Sensors (In Lab and Remote), Functional Testing & Patient Reported Outcomes, and Remote Wearable Sensor Assessment
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Deep Phenotyping Gait Deficits in Orthopedic Manifestations of Pediatric Cancer Patients
- Plain-language title
- Measuring Walking Problems in Children and Young People After Sarcoma SurgeryGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 13 November 2026.
- Fit questions
- Built from NCT07502885, who can take part
- Record updated
- 18 June 2026