The Orienting Study
Key facts
- Who runs it
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
- Where
- Milan, ItalySee the site
- Trial code
- Status
- Recruiting
- People taking part
- 450 people, planned
- Started
- 30 Oct 2024
- Expected to end
- 30 Oct 2039
- Type of study
- Observational, 3 groups
- Record updated
- 31 March 2026
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 17 criteriaShow less
Other criteria
- The inclusion criteria for CPPD patients are:
- Patients diagnosed with CPPD disease according to the ACR/EULAR 2023 classification criteria
- Patients with evidence of asymptomatic CPPD on US or X-rays (not meeting the classification criteria) according to validated imaging definitions
- Aged older than 18 years
- Able to provide informed consent, according to requirements of local IRB/ethics committee; The inclusion criteria for gout patients are:
- Patients diagnosed with gout according to the ACR/EULAR 2015 classification criteria
- Aged older than 18 years
- Able to provide informed consent, according to requirements of local IRB/ethics committee; The inclusion criteria for disease controls are:
- A diagnosis of OA according to ACR classification criteria
- No evidence of uric acid or calcium pyrophosphate deposits on US
- Uric acid < 6 mg/dL
- Aged older than 18 years
- Able to provide informed consent, according to requirements of local IRB/ethics committee; The exclusion criteria for gout/CPPD patients are:
- Known history of other inflammatory arthropathies
- Unable to provide informed consent, according to requirements of local IRB/ethics committee; The exclusion criteria for disease controls are:
- Known history of other inflammatory arthropathies
- Unable to provide informed consent, according to requirements of local IRB/ethics committee
Where in Italy
- IRCCS Ospedale Galeazzi Sant'AmbrogioMilan, ItalyContact: Alessandro LuciaTaking people
About the trial
What the trial wants to find out
This study at IRCCS Galeazzi - Sant'Ambrogio Hospital involves patients with gout, CPPD, and osteoarthritis as a control group. Patients will receive routine care with regular clinical, laboratory, and imaging assessments every six months, alongside urgent visits as needed. The study aims to understand crystal deposits in joints and blood vessels and monitor their progression over time, assessing how these deposits respond to standard treatments and if they are associated with cardiovascular complications. Data will be collected from medical records over a follow-up period of up to 10 years, offering long-term insights into disease impact and treatment effectiveness.
The 3 groups in the trial
- Gout
Patients affected by gout according to ACR/EULAR classification criteria
- CPPD
Patients affected by gout according to ACR/EULAR classification criteria
- Disease control
Patients with a diagnosis of osteoarthritis according to ACR classification criteria
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- The Natural History Of Calcium Pyrophosphate Deposition And Gout: An Observational Clinical And Imaging Study - The Orienting Study
- Record updated
- 31 March 2026