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Registry of swallowing tube movement tests in adults with esophageal disorders

Records esophageal test results in adults with reflux, achalasia or related motility disorders.

Key facts

Who runs it
IRCCS San Raffaele
Where
Italy1 site in 1 countryChoose a country to see its sites
Trial code
Registry title
PRospective Registry of Esophageal Motility
Status
Recruiting
People taking part
10,000 people, planned
Started
9 Mar 2026
Expected to end
Mar 2041
Type of study
Observational
Record updated
2 April 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with reflux symptoms or swallowing problems who are sent for esophageal motility tests. These tests check how the food pipe (esophagus) moves. It is a registry, so no treatment is given.

Age
Over 18 years.
Sex
All sexes.
Disease stage
Typical reflux symptoms (heartburn, regurgitation) or atypical ones, for example in the throat, lungs or during sleep. People with blockage symptoms, such as trouble swallowing, chest pain or food getting stuck, can also join. People with esophageal inflammation (such as EoE) or rheumatic diseases such as scleroderma can join.
Earlier treatment
People who had anti-reflux surgery, weight-loss (bariatric) surgery, or esophageal or stomach myotomy can join. Myotomy is a cut in the muscle, done by endoscopy or surgery.

Main reasons for not taking part

  • Younger than 18 years
  • Not willing to give informed consent to join the registry
  • Not referred to the Digestive Physiopathology Unit of IRCCS San Raffaele Hospital for motility tests

The registry criteria, word for word

Show all 7 criteriaShow less

Who can take part

  • Participant is willing and able to give informed consent for participation in the study
  • The procedures are the standard of care for the patient or the participant is taking the medicinal product according to clinical practice
  • Aged > 18 years
  • Any typical (heartburn or regurgitation) or atypical reflux symptom (Laryngeal Cough, laryngitis, sub-glottic stenosis, globus, laryngeal cancer, vocal cord granuloma, vocal cord irritation, vocal cord polyps and post-nasal drip; Oropharyngeal: Dental erosion, pharyngitis, sore or burning throat, gingivitis and halitosis; Ears and sinuses: Earaches, otitis media and sinusitis; Pulmonary: Chronic bronchitis, pneumonia, aspiration, bronchiectasis, asthma and idiopathic pulmonary fibrosis; Cardiac: Arrhythmia, angina and myocardial infarction; Sleep: Sleep apnoea, sleep deprivation, insomnia, snoring, nightmare and sleep disturbance), but also any obstructive esophageal symptom potentially reflecting a primary or secondary motility disorder (oropharyngeal or esophageal dysphagia, chest pain, bolus impaction). Every patient with a diagnosis of esophageal inflammatory disorder (including EoE and others) or systemic rheumatological condition (scleroderma, systemic sclerosis, lichen planus and others), every patient previously undergone to any anti-reflux surgery, bariatric surgery, endoscopic or surgical esophageal or gastric myotomy (also for gastroparesis) may be included
  • Patients must be referred to the Digestive Physiopathology Unit of IRCCS San Raffaele Hospital for motility tests

Who cannot take part

  • Age < 18 years
  • Not willing to provide informed consent to the inclusion in the registry

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

Digestive physiopathology is a branch of gastroenterology aiming to study patients with upper GI symptoms, mainly gastro-esophageal, potentially indicating the presence of Gastroesophageal Reflux Disease (GERD)/Barrett Esophagus (BE) or obstructive esophageal motility disorders (achalasia being the most relevant), but including also other primary motility disorders such as Esophgago-Gastric Junction Outflow Obstruction (EGJOO), Hypercontractile Esophagus (HE), Distal Esophageal Spasm (DES) and other minor disorders. Physiopathological testing encompasses High-Resolution Manometry (HRM), 24-H esophageal pH-impedance testing, Functional Lumen Imaging Probe (FLIP) assessment. All these tests are designed to provide a clear phenotyping of esophago-gastric disorders related to reflux or obstructive esophageal symptoms, either in naïve patients, as well as after foregut surgery (particularly anti-reflux surgery, achalasia/primary motility disorders treatment).

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

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Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
PRospective Registry of Esophageal Motility
Plain-language title
Registry of swallowing tube movement tests in adults with esophageal disordersGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 15 November 2026.
Record updated
2 April 2026