A simple exercise breathing test to estimate risk in lung cancer treatment
Tests a simple cycling and breathing check for complication risk in lung cancer.
Plain-language title generated from the registry record
Registry title: Simplified Exercise-based Risk Assessment in Lung Cancer
Key facts
- Where
- Jönköping, Kalmar, Karlskrona, Linköping, and Lund, SwedenSee the 5 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with a lung cancer diagnosis. They do a simple, low-intensity cycling test so researchers can study the risk of complications before treatment.
- Age
- 18 years or older
- Sex
- All sexes can join
- Disease stage
- Lung cancer diagnosis
Main reasons for not taking part
- Not able to do cycle ergometer exercise
- Not able to understand spoken or written Swedish
Read by machine on 12 November 2026.
Where in Sweden
- Department of Pulmonology, RyhovJönköping, SwedenContact: Magnus Kentson, MD, PhDNo longer taking part
- Department of Pulmonology, Kalmar County HospitalKalmar, SwedenContact: Niels Hornstra, MDNo longer taking part
- Department of Pulmonology, Blekinge HospitalKarlskrona, SwedenContact: Magnus Ekström, MD, PhDNo longer taking part
- Department of Pulmonology, University HospitalLinköping, SwedenContact: Gabriel Högström, MD, PhDNo longer taking part
- Department of Clinical PhysiologyLund, SwedenContact: Henrik Mosén, MD, PhDNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Linkoeping University
- Trial code
- NCT07506889
- Record updated
- 8 April 2026
- Original description
Physiological evaluation is part of the preoperative risk estimation in patients with lung cancer, and it aids in the choice of treatment. Ventilatory efficiency during exercise has emerged as a strong predictor of major postoperative complications, so far determined during a maximal cardiopulmonary exercise test. However, this test is limited by its availability and high cost, due to the requirement of high-technological equipment and advanced expertise. The current project aims to evaluate a simplified and accessible method for risk evaluation before decision on treatment in lung cancer. It builds on recent advances in technology and knowledge and combines a simple, low-intensity cycling test with measurement of ventilatory efficiency (end-tidal carbon dioxide pressure) with a handheld monitor. In a prospective, multi-center design the investigators will include patients evaluated for suspected lung cancer. The main objective is to establish threshold values for end-tidal carbon dioxide associated with low respectively high risk of major complications in patients undergoing surgery. In addition, the study aims to determine if end-tidal carbon dioxide can predict severe side-effects during neoadjuvant or curatively aiming systemic therapy. The project is closely linked to clinical practice, and the results can be easily implemented due to the simple and cost-efficient methodology. the suggested simplified approach would also allow access to physiological evaluation where more advanced methods are unavailable.Read full original descriptionShow less
EXercise-based Evaluation of Ventilatory Efficiency for enHanced Risk Assessment in Lungcancer trEatment Using End-tidal CO2: a Multicenter, Prospective Study
Physiological evaluation is part of the preoperative risk estimation in patients with lung cancer, and it aids in the choice of treatment. Ventilatory efficiency during exercise has emerged as a strong predictor of major postoperative complications, so far determined during a maximal cardiopulmonary exercise test. However, this test is limited by its availability and high cost, due to the requirement of high-technological equipment and advanced expertise. The current project aims to evaluate a simplified and accessible method for risk evaluation before decision on treatment in lung cancer. It builds on recent advances in technology and knowledge and combines a simple, low-intensity cycling test with measurement of ventilatory efficiency (end-tidal carbon dioxide pressure) with a handheld monitor. In a prospective, multi-center design the investigators will include patients evaluated for suspected lung cancer. The main objective is to establish threshold values for end-tidal carbon dioxide associated with low respectively high risk of major complications in patients undergoing surgery. In addition, the study aims to determine if end-tidal carbon dioxide can predict severe side-effects during neoadjuvant or curatively aiming systemic therapy. The project is closely linked to clinical practice, and the results can be easily implemented due to the simple and cost-efficient methodology. the suggested simplified approach would also allow access to physiological evaluation where more advanced methods are unavailable.
Inclusion: Lung Cancer Diagnosis; Age of at least 18 years.
Exclusion: Not able to perform cycle ergometer exercise; Not able to understand spoken or written Swedish.