Shorter radiation before surgery for soft tissue sarcoma of the limbs or trunk wall
Tests a shorter radiation course before surgery in adults with limb or trunk sarcoma.
Plain-language title generated from the registry record
Registry title: Assessment of the Long-term Efficacy of Moderately Hypofractionated Neoadjuvant Radiotherapy Soft Tissue Sarcoma in the Limbs or Trunk Wall
Key facts
- Where
- Lille, FranceSee the site
- Phase
- Phase 2
Where in France
- Centre Oscar LambretLille, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Centre Oscar Lambret
- Trial code
- NCT07507773
- Record updated
- 23 July 2026
- Original description
This trial aims to assess the long-term efficacy of moderately hypofractionated neoadjuvant radiotherapy for soft tissue sarcoma in the limbs or trunk wall. The primary outcome is local disease control, assessed by the cumulative incidence of progression/recurrence.Read full original descriptionShow less
Phase II Clinical Trial Assessing the Long-term Efficacy of Moderately Hypofractionated Neoadjuvant Radiotherapy Soft Tissue Sarcoma in the Limbs or Trunk Wall, Incorporating Translationnal Research
This trial aims to assess the long-term efficacy of moderately hypofractionated neoadjuvant radiotherapy for soft tissue sarcoma in the limbs or trunk wall. The primary outcome is local disease control, assessed by the cumulative incidence of progression/recurrence.
After informed consent has been obtained and eligibility criteria have been checked, a baseline assessment will be performed followed by the experimental treatment: intensity-modulated radiotherapy with a moderately hypofractionated regimen consisting in 15 fractions of 2.7 Gy administered over 3 weeks.
a follow-up assessment will be performed 3 to 4 weeks after the last radiotherapy session.
Tumor resection will be performed 4 to 8 weeks after the radiotherapy. Patients will then be followed up until the end of the study; planned 5 years after the last inclusion.
Radiotherapy will be evaluated in terms of safety and efficacy.
Inclusion: Patient aged ≥ 18 years ; Localised sarcoma of a limb, the root of a limb, or the trunk wall ; Histologically confirmed diagnosis of soft tissue sarcoma regardless of the grade ; Diagnosis biopsy performed at Centre Oscar Lambret, with specimen available for translational research ; Indication of neoadjuvant radiotherapy according to the multidisciplinary consultation meeting ; Tumor considered operable with a curative intent and conservative intent according to the multidisciplinary consultation meeting ; Affiliation to the French National Social Security System ; Informed and signed consent.
Exclusion: Tumor considered inoperable even after radiotherapy, according to the multidisciplinary consultation meeting ; Indication of neoadjuvant or adjuvant chemotherapy ; Metastatic disease (including local lymph node diffusion) ; Visceral or retroperitoneal sarcoma ; Ewing tumor of soft tissue, desmoid tumor, embryonal or alveolar rhabdomyosarcoma ; Pregnant or breastfeeding women ; Patients under protective measures ; Patient refusal.