Reviews how breathing support is chosen for COPD flare-ups in hospital
Looks back at hospital records of people with COPD flare-ups receiving breathing support.
Plain-language title generated from the registry record
Registry title: Decision-making and Optimization of Ventilatory Support for AECOPD Patients
Key facts
- Where
- Hangzhou, ChinaSee the site
Where in China
- Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhou, ChinaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Sir Run Run Shaw Hospital
- Trial code
- NCT07508943
- Record updated
- 2 April 2026
- Original description
The goal of this retrospective observational study is to learn about how respiratory support is selected and adjusted in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The main questions it aims to answer are:Read full original descriptionShow less
Decision-making and Optimization of Ventilatory Support for AECOPD Patients
The goal of this retrospective observational study is to learn about how respiratory support is selected and adjusted in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The main questions it aims to answer are:
1. How are different respiratory support modalities selected for patients with AECOPD in real-world practice? 2. What clinical patterns are associated with escalation, de-escalation, switching, or discontinuation of respiratory support during hospitalization? Researchers will review de-identified hospital records of patients admitted with AECOPD and analyze the dynamic use of respiratory support during hospitalization, including conventional oxygen therapy, high-flow nasal cannula oxygen therapy, non-invasive ventilation, and invasive mechanical ventilation.
Participants will not receive any study-assigned intervention. The study will use existing clinical data collected during routine inpatient care and will not change diagnosis, treatment, or follow-up.
Inclusion: Hospitalized patients with a documented diagnosis of acute exacerbation of chronic obstructive pulmonary disease; Patients identified retrospectively from hospital records during the predefined study period; Patients who received at least one form of respiratory support during the index hospitalization, including conventional oxygen therapy, high-flow nasal cannula oxygen therapy, noninvasive ventilation, or invasive mechanical ventilation; Patients with available clinical records containing sufficient dynamic physiological, laboratory, and treatment-related data for retrospective analysis.
Exclusion: Patients admitted primarily for other acute conditions, including but not limited to pneumonia without documented AECOPD, acute heart failure, pulmonary embolism, pneumothorax, asthma exacerbation, trauma, or postoperative care; Patients whose hospitalization was not primarily due to acute exacerbation of COPD, even if COPD was documented as a comorbidity; Patients with stable COPD and no evidence of acute exacerbation during the index hospitalization; Patients with insufficient documentation to confirm AECOPD as the primary reason for admission; Patients with incomplete clinical records preventing retrospective analysis; Repeated hospitalizations of the same patient during the study period, with only the first eligible admission included.