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NCT07512310Completed

Non-Invasive and Invasive Assessment of Heart Filling Pressure

NIPRESS: Non-Invasive and Invasive Pressure Evaluation and Stratification Study

Source: ClinicalTrials.gov · Last updated 6 Apr 2026

Brief summary (registry, in English)

This study evaluates how different non-invasive and invasive measurements reflect left ventricular filling pressure, an important indicator of cardiac function. Elevated filling pressure is associated with symptoms such as shortness of breath and plays a central role in the diagnosis and management of heart failure and pulmonary hypertension. In clinical practice, filling pressure can be estimated using echocardiography or measured during cardiac catheterisation. However, the relationships between these measurements and their ability to accurately reflect true filling pressure are not fully understood. This retrospective study includes patients who underwent cardiac catheterisation with invasive haemodynamic assessment and temporally related echocardiographic evaluation as part of routine clinical care. The aim is to improve understanding of how different measurements relate to each other and to identify which parameters best reflect elevated filling pressure. The results are expected to support more accurate interpretation of haemodynamic measurements and improve clinical decision-making, particularly regarding the use of non-invasive versus invasive assessment.

Status (registry)
Completed
Study type
Observational
Enrollment
623 (actual)
First submitted
30 Mar 2026
Start date
15 Mar 2018
Primary completion date
14 Mar 2024
Lead sponsor
University Hospital, Essen
NCT number
NCT07512310

What you commit to

  • Study type: Observational
  • Participants enrolled: 623
  • From 15 Mar 2018 to the primary completion date, 14 Mar 2024
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other

  • Missing or incomplete invasive haemodynamic measurements (LVEDP or PCWP)
  • Missing or non-interpretable echocardiographic data
  • Haemodynamic instability at the time of measurement
  • Incomplete data required for analysis

Who the study is looking for

  • Adult patients (≥18 years)
  • Clinically indicated left- and right-heart catheterisation under resting conditions
  • Availability of invasive left ventricular end-diastolic pressure (LVEDP) measurement
  • Availability of pulmonary capillary wedge pressure (PCWP) measurement
  • Availability of transthoracic echocardiography within 5 days of cardiac catheterisation
  • Adequate echocardiographic image quality for analysis

Age in the registry: 18 years to - · Sex: All

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
West German Heart and Vascular Centre Essen, University Hospital Essen
Coordinator of this site? Confirm its status
EssenGermanyUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.