NCT07513844Recruiting
Optimizing Parameters of Low-Intensity Focused Ultrasound for Pallidal Modulation in Huntington's Disease
Low-Intensity Focused Ultrasound Stimulation of the External Globus Pallidus in Huntington's Disease: A Phase I/II Safety and Feasibility Trial
Source: ClinicalTrials.gov · Last updated 29 Apr 2026
Brief summary (registry, in English)
The purpose of this research study is to determine the optimal pulse repetition frequency of low-intensity focused ultrasound that is safe and effective in improving motor symptoms in patients with Huntington's disease.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 24 (estimated)
- First submitted
- 24 Mar 2026
- Start date
- 20 Apr 2026
- Primary completion date
- 31 Oct 2026
- Lead sponsor
- First Affiliated Hospital of Fujian Medical University
- Diseases
- Huntington's disease
- NCT number
- NCT07513844
What you commit to
- Study type: Interventional
- Planned participants: 24
- From 20 Apr 2026 to the primary completion date, 31 Oct 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior treatment with electroconvulsive therapy, transcranial magnetic stimulation, transcranial direct current stimulation, transcranial alternating current stimulation, or other neuromodulation therapies within the past 3 years
- Concurrent participation in another interventional clinical trial
Other illness
- History of self-injury, aggressive behavior, or unstable psychiatric disorders
- History of head injury or neurosurgical procedure
- Presence of intracranial implants, metallic foreign bodies, cochlear implants, or cardiac pacemakers
- Severe systemic disease, pregnancy, or breastfeeding
- Any other condition that, in the opinion of the investigator, would preclude participation
Other
- Contraindications to magnetic resonance imaging, ultrasound, or anesthesia
- Severe brain atrophy with unclear external globus pallidus structure on MRI
Who the study is looking for
- Aged 18 to 75 years (inclusive)
- Genetically confirmed Huntington's disease with HTT CAG repeat length of 40 or greater
- Unified Huntington's Disease Rating Scale Total Maximal Chorea score of 8 or higher on a scale of 0 to 28, with higher scores indicating more severe chorea
- Huntington's Disease Integrated Staging System stage 2 or 3
- Willing to participate and provide informed consent
- Have a reliable caregiver available
- No severe cognitive impairment that would preclude reliable reporting of adverse events or efficacy during treatment
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of Rehabilitation Medicine, The First Affiliated Hospital of Fujian Medical University Coordinator of this site? Confirm its status | Fuzhou | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.