SLIT ABS: Study on Patients With Autoimmune Podocytopathy
Key facts
- Who runs it
- Meyer Children's Hospital IRCCS
- Where
- Rochester, United StatesSee the siteAlso in 4 other countries, 13 sites
- Trial code
- Status
- Recruiting
- People taking part
- 50 people, planned
- Started
- 10 Jun 2025
- Expected to end
- Oct 2036
- Type of study
- Interventional
- Treatments tested
- Serum and renal tissue analysis
- Record updated
- 8 April 2026
Who can take part
- Age
- 0 years to 99 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 8 criteriaShow less
Who can take part
- Pediatric and adult patients with a diagnosis of podocytopathy
- Patients with nephrotic syndrome and/or histological diagnosis of minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), collapsing glomerulopathy (CG), or diffuse mesangial sclerosis (DMS)
- Both newly diagnosed (incident) patients and patients already under follow-up at participating centers
- Availability of clinical data from medical records (including paper and/or electronic records, laboratory reports, and discharge summaries)
- Availability of biological samples (e.g., blood and/or renal biopsy), if collected as part of routine clinical care
- Signed informed consent by the patient or legal guardian (and assent when applicable)
Who cannot take part
- Refusal or inability of the patient, parents, or legal guardian to provide informed consent
- Lack of sufficient clinical data or unavailable biological samples required for the study
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 0 and 99 years old?
Where in United States
Also in 4 other countries, 13 sites
- Mayo ClinicRochester, United StatesContact: Paola Romagnani, MD, PhDNot yet recruiting
About the trial
What the trial wants to find out
Nephrotic syndrome is a kidney condition that mainly affects children and is characterized by high levels of protein in the urine, low levels of protein in the blood, and swelling. While many children respond well to steroid treatment, a large proportion experience relapses or become dependent on therapy. In some cases, the disease does not respond to standard treatments and may progress to chronic kidney disease.
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Recent research suggests that, in addition to genetic factors, immune system mechanisms may play a key role in the development and progression of nephrotic syndrome. In particular, some patients produce autoantibodies against nephrin, an essential protein of the kidney filtration barrier. These autoantibodies may be associated with disease activity and treatment response.
The aim of this study is to investigate the presence of anti-nephrin autoantibodies in children with nephrotic syndrome and to better understand their role in disease mechanisms and clinical outcomes.The study will also explore the presence of other autoantibodies targeting components of the glomerular filtration barrier. The study will use advanced laboratory techniques, including blood tests and detailed analysis of kidney biopsy samples, to identify these antibodies and their relationship with kidney structure and function.
By integrating laboratory findings with clinical data, this study aims to improve the understanding of nephrotic syndrome and support the development of more personalized diagnostic and therapeutic strategies, with the goal of improving patient outcomes and reducing unnecessary or ineffective treatments.
The group in the trial
- Pediatric and adult patients with podocytopathiesTreatment being tested
Participants are not assigned to therapeutic interventions. Serum and renal biopsy samples obtained during routine clinical care are collected and analyzed for research purposes, including ELISA testing for anti-nephrin antibodies, others anti-slit antibodies and advanced microscopy evaluation.
Treatment: Serum and renal tissue analysis
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Validation and Implementation of Diagnostic Techniques for the Detection of Circulating Factors in Patients With Autoimmune Podocytopathy
- Fit questions
- Built from NCT07516964, who can take part
- Record updated
- 8 April 2026