Brain stimulation at home for movement symptoms of Parkinson's disease
Tests a home brain stimulation device against a sham device in Parkinson's disease.
Plain-language title generated from the registry record
Registry title: Remotely Supervised Home-based Transcranial Temporal Interference Stimulation on Motor Symptoms in Parkinson's Disease
Key facts
- Where
- Shanghai, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 80 years old?
Source: NCT07518290, who can take part
Where in China
- Shanghai University of SportShanghai, ChinaNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Shanghai University of Sport
- Trial code
- NCT07518290
- Record updated
- 22 September 2026
- Original description
The goal of this clinical trial is to learn if home-based temporal interference stimulation (TIS) works to improve motor symptoms in people with Parkinson's disease (PD). It will also learn about the safety of this treatment. The main questions it aims to answer are:Read full original descriptionShow less
Remotely Supervised Home-based Transcranial Temporal Interference Stimulation on Motor Symptoms in Parkinson's Disease: Protocol For a Double Blind Randomized Controlled Trial
The goal of this clinical trial is to learn if home-based temporal interference stimulation (TIS) works to improve motor symptoms in people with Parkinson's disease (PD). It will also learn about the safety of this treatment. The main questions it aims to answer are:
1. Does home-based TIS improve movement problems such as slow movement, stiffness, and walking difficulty? 2. Are the effects maintained after the treatment ends? 3. What medical problems (adverse events) occur during treatment? Researchers will compare active TIS to a sham treatment (a look-alike procedure that does not deliver active stimulation) to see if TIS works.
Participants will:
1. Receive active TIS or sham stimulation once a day for 4 weeks at home under remote supervision 2. Visit the clinic at specific time points for movement assessments 3. Complete online questionnaires about symptoms and quality of life
Inclusion: Diagnosis of Parkinson's disease according to established clinical criteria; Mild-to-moderate disease severity, defined as Hoehn and Yahr stage 1.5-3; Age between 40 and 80 years; Stable anti-parkinsonian medication regimen; Ability to walk unaided for at least 2 minutes.
Exclusion: diagnosis of other neurological conditions such as multiple sclerosis, previous stroke; significant cognitive impairment as defined by the diagnosis of Alzheimer's disease or dementia, or Montreal Cognitive Assessment (MoCA) total score<21, a recommended threshold for dementia in PD; physician-diagnosis of schizophrenia or other psychiatric illness; contraindications to TIs (e.g., metal implantation, pacemakers, etc.); the use of DBS; report of severe lower-extremity arthritis, pain, or orthopedic problems significantly affecting gait; an unwillingness to cooperate or participate in the study protocol. Eligible and interested participants will then be enrolled and complete baseline assessments before the randomization.