A Special Diet to Help Manage Ulcerative Colitis
Tests a high protein, high fiber diet in adults with ulcerative colitis.
Plain-language title generated from the registry record
Registry title: Microbiome-targeted Diet Therapy in Ulcerative Colitis
Key facts
- Where
- Minneapolis, United StatesSee the site
Where in United States
- University of MinnesotaMinneapolis, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Minnesota
- Trial code
- NCT07520461
- Record updated
- 9 November 2026
- Original description
The central objective of this proposal is to test a novel diet capable of meeting the elevated protein requirements in ulcerative colitis (UC), while simultaneously decreasing microbial hydrogen sulfide (H2S) production in the colon with fiber.Read full original descriptionShow less
Microbiome-targeted Diet Therapy in Ulcerative Colitis
The central objective of this proposal is to test a novel diet capable of meeting the elevated protein requirements in ulcerative colitis (UC), while simultaneously decreasing microbial hydrogen sulfide (H2S) production in the colon with fiber.
Inclusion: Ability and willingness to provide informed consent; Age at least 18 years old; Diagnosis of UC based on clinical and endoscopic criteria; UC duration of at least 3 months; Ulcerative Colitis Endoscopic Index of Severity (UCEIS) score ≤4 within 90 days of randomization; On a stable dose or no existing UC therapies (apart from steroids) for defined periods (as outlined below); ≥4 weeks if no medication, 5-ASA; ≥8 wk for immunomodulatory therapy; ≥12 wk for biologics; Ability to comply with study requirements in the opinion of the primary investigator.
Exclusion: Ongoing alcohol or drug abuse; History of stomach surgery or bowel resection; History of anaphylactic food allergies; Moderate or severe UC as defined by UCEIS ≥5; Antibiotic use within 3 months; Anticipated antibiotic exposure during the study period (e.g. perioperative antibiotics); Pregnancy or breastfeeding; Intolerance of high dietary fiber content; Habitual vegan diet pattern; Insufficient freezer space to accommodate meal delivery.