Brain stimulation and brain-activity markers to predict arm recovery after ischemic stroke
Tests magnetic brain stimulation against a sham in people after ischemic stroke.
Plain-language title generated from the registry record
Registry title: Neurophysiological Markers for Prediction of Rehabilitation Outcomes After Ischemic Stroke
Key facts
- Where
- Moscow, RussiaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 65 years old?
Source: NCT07520630, who can take part
Where in Russia
- Moscow Scientific and Practical Center of Medical Rehabilitation, Restorative and Sports MedicineMoscow, RussiaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Moscow Scientific and Practical Center of Medical Rehabilitation, Restorative and Sports Medicine
- Trial code
- NCT07520630
- Record updated
- 9 April 2026
- Original description
The goal of this randomized controlled study is to develop and validate an integrated neurophysiological model for predicting rehabilitation potential in patients with ischemic stroke. The study focuses on identifying objective markers of brain activity associated with motor preparation and recovery.Read full original descriptionShow less
Neurophysiological Markers for Developing an Integrative Model of Rehabilitation Prognosis in Patients With Ischemic Stroke
The goal of this randomized controlled study is to develop and validate an integrated neurophysiological model for predicting rehabilitation potential in patients with ischemic stroke. The study focuses on identifying objective markers of brain activity associated with motor preparation and recovery.
The project includes two stages. First, healthy volunteers will participate in experimental motor and mental tasks to establish reference patterns of brain activity using electroencephalography and transcranial magnetic stimulation. These data will be used to define stable neurophysiological markers of motor network function.
In the second stage, patients in the acute and early recovery phases after ischemic stroke will be randomly assigned to receive either active intermittent theta-burst stimulation of the motor cortex or a sham procedure, in addition to standard rehabilitation. Brain activity and clinical motor function will be assessed before and after the intervention.
The study aims to determine which neurophysiological measures are sensitive to neuromodulation and are associated with clinical improvement, in order to construct a predictive model of rehabilitation outcome.
Participants will [describe the main tasks participants will be asked to do, interventions they'll be given and use bullets if it is more than 2 items].
Inclusion: First-ever ischemic stroke confirmed by CT/MRI; 5 days - 6 months post-stroke; Age 40-65; MoCA ≥20; HADS <11 for anxiety and depression; MRC 2-4 in upper limb; Modified Ashworth Scale ≤3; Signed informed consent.
Exclusion: Epilepsy; Severe cardiac arrhythmias; Decompensated somatic disease; Implanted electronic devices; Intracranial aneurysm; Pregnancy/lactation.
Experimental phase:; will include healthy volunteers without contradictions to TMS; Clinical phase:.