Lily's Grace Temporal Interference
Key facts
- Where
- Madison, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Where in United States
- UW School of Medicine and Public HealthMadison, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Wisconsin, Madison
- Trial code
- NCT07520955
- Record updated
- 30 October 2026
- Original description
This study is to evaluate the effectiveness of targeted Transcranial Electrical Stimulation with Temporal Interference (TES-TI) interventions to boost Non-Rapid Eye Movement (NREM) sleep, decrease seizures and promote emotional health in patients with epilepsy. Up to 24 participants (8 control participants for technical optimization prior to recruitment and 16 patients with epilepsy) will be enrolled and can expect to be on study for up to 24 months.Read full original descriptionShow less
Using Temporal Interference to Non-Invasively Enhance Sleep Homeostasis in Patients With Epilepsy
This study is to evaluate the effectiveness of targeted Transcranial Electrical Stimulation with Temporal Interference (TES-TI) interventions to boost Non-Rapid Eye Movement (NREM) sleep, decrease seizures and promote emotional health in patients with epilepsy. Up to 24 participants (8 control participants for technical optimization prior to recruitment and 16 patients with epilepsy) will be enrolled and can expect to be on study for up to 24 months.
Inclusion: English-speaking (able to provide consent and complete questionnaires); Citizen or holding permanent resident status; History of refractory epilepsy with intractable seizures and/or cognitive decline.
Exclusion: Dental implants; Any current or past history of neurological disorders or acquired neurological disease other than epilepsy (e.g. stroke, traumatic brain injury), including intracranial lesions; Current history of poorly controlled headaches including intractable or poorly controlled migraines; Any systemic illness or unstable medical condition that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc.); Any medical devices or implants (i.e. cardiac pacemaker, medication infusion pump, cochlear implant, vagal nerve stimulator) unless otherwise approved by the responsible MD; Possible pregnancy or plan to become pregnant in the next 6 months; Any metal in the head; Any metal in the body; Permanent retainers; Claustrophobia (a fear of small or closed places); Back problems that would prevent lying flat for several hours; Regular night-shift work (second or third shift).