Black Seed Oil Compared With Steroid Ear Drops for Eczema of the Ear Canal
Compares Nigella sativa oil with mometasone furoate ear drops in adults with eczematous otitis externa.
Key facts
- Who runs it
- Bezmialem Vakif University
- Where
- Istanbul, TürkiyeSee the site
- Trial code
- Registry title
- Nigella Sativa Oil for Eczematous Otitis Externa
- Status
- Recruiting
- People taking part
- 85 people, planned
- Started
- 12 Jan 2026
- Planned end
- Jul 2026
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Mometasone Furoate (MF)
- Nigella sativa oil
- Record updated
- 21 April 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with eczema of the outer ear canal (eczematous otitis externa) who have ear symptoms. It compares Nigella sativa oil with mometasone furoate ear drops.
- Age
- 18 years and older
- Sex
- All sexes can join.
- Disease stage
- Eczematous otitis externa confirmed by an ear exam, with at least one symptom: itching, discomfort, ear discharge, or pain.
- Earlier treatment
- People cannot have used steroid medicines or other ear medicines within a set period before joining. The record does not give the length of that period.
Main reasons for not taking part
- Allergy to Nigella sativa oil or mometasone furoate
- Ear infection that needs antibiotics
- Ear surgery or structural problems of the ear canal in the past
- Severe general illness that may interfere with the trial
- Pregnant or breastfeeding women
The registry criteria, word for word
Show all 10 criteriaShow less
Who can take part
- Adult patients aged 18 years and older
- Clinical diagnosis of eczematous otitis externa confirmed by otoscopic examination
- Presence of at least one symptom related to the affected ear (itching, discomfort, otorrhea, or pain)
- Willingness to participate and ability to provide written informed consent
Who cannot take part
- Use of topical or systemic corticosteroids or other ear medications within a defined period prior to enrollment
- Known hypersensitivity or allergic reaction to Nigella sativa oil or mometasone furoate
- History of ear surgery or structural abnormalities of the external auditory canal
- Severe systemic disease or condition that may interfere with study participation
- Presence of acute otitis externa of infectious origin requiring antibiotic treatment
- Pregnant or breastfeeding women
Where in Türkiye
- Bezmialem Vakif UniversityIstanbul, TürkiyeContact: Nazan Degirmenci, Assoc. Prof.Taking people
About the trial
What the trial wants to find out
Eczematous otitis externa is a common inflammatory condition of the external auditory canal characterized by itching, discomfort, discharge, and pain. Topical corticosteroids are widely used for treatment; however, alternative therapies with fewer side effects are of increasing interest.
Read full original descriptionShow less
This study aims to compare the efficacy of Nigella sativa (black seed) oil and mometasone furoate ear drops in the treatment of eczematous otitis externa. Nigella sativa is a natural product with known anti-inflammatory and antimicrobial properties.
In this randomized, controlled clinical trial, adult patients with eczematous otitis externa will be assigned to receive either Nigella sativa oil or mometasone furoate ear drops for 10 days. Clinical symptoms and inflammatory findings will be evaluated at baseline and after treatment.
The objective of this study is to determine whether Nigella sativa oil is an effective and safe alternative to topical corticosteroid therapy.
The 2 groups in the trial
- nigella sativaTreatment being tested
Participants in this group will receive Nigella sativa oil ear drops, administered as two drops into the affected ear twice daily for 10 days.
Treatment: Nigella sativa oil
- mometasone furoateExisting treatment, for comparison
Participants in this group will receive mometasone furoate 0.1% ear drops, administered as two drops into the affected ear twice daily for 10 days.
Treatment: Mometasone Furoate (MF)
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Efficacy of Nigella Sativa Oil in Eczematous Otitis Externa: A Randomized Controlled Study
- Plain-language title
- Black Seed Oil Compared With Steroid Ear Drops for Eczema of the Ear CanalGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 13 November 2026.
- Record updated
- 21 April 2026