Extra scans to adapt radiation plans in children with tumors outside the brain
Tests extra imaging scans during radiation treatment in children with non-brain tumors.
Plain-language title generated from the registry record
Registry title: Hypersight and Ethos In Pediatric Radiotherapy
Key facts
- Where
- Toronto, CanadaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for children and teenagers aged 18 or under who are getting radiation therapy for a tumour outside the head. They will have extra scans twice a week.
- Age
- 18 years or under
- Sex
- All sexes can join.
- Disease stage
- Non-cranial tumours (tumours that are not in the skull or brain). The record gives no stage.
Main reasons for not taking part
- Primary cranial tumours (tumours that start in the skull or brain)
- Fewer than 5 days of radiation therapy
Read by machine on 12 November 2026.
Where in Canada
- Princess Margaret Cancer CentreToronto, CanadaContact: Dana Keilty, MDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- University Health Network, Toronto
- Trial code
- NCT07528547
- Record updated
- 15 April 2026
- Original description
This is a single-center, prospective pilot study evaluating the utility of HyperSight CBCT imaging and Ethos adaptive radiation planning in pediatric patients receiving radiation therapy for non-cranial tumors.Read full original descriptionShow less
Hypersight and Ethos In Pediatric Radiotherapy (Peds Ethos)
This is a single-center, prospective pilot study evaluating the utility of HyperSight CBCT imaging and Ethos adaptive radiation planning in pediatric patients receiving radiation therapy for non-cranial tumors.
Twenty patients aged 18 or under will be enrolled. Participants will receive standard-of-care radiation therapy, with the addition of twice-weekly HyperSight CBCT scans. These scans will be used to assess anatomical changes and generate adapted radiation plans using the Ethos platform. Radiation oncologists and radiation therapists will independently evaluate the need for adaptation, and adapted vs. scheduled plans will be compared using dosimetric and anatomical similarity metrics.
An optional sub-study will allow anonymized imaging and planning data to be shared with Varian Medical Systems. The study duration will match the patient's treatment course, typically 1-6 weeks, with no additional follow-up beyond standard care.
Inclusion: Patient (paediatric or adolescent) age 18 or under receiving at least 5 days of radiation therapy; Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 3.
Exclusion: Patients with primary cranial tumours will be excluded due to the low expected utility of non-contrast CT scans in the delineation of brain edema and brain substructures.