How self-awareness relates to social understanding in frontotemporal dementia and Alzheimer's disease
Studies self-awareness and social skills in people with behavioral frontotemporal dementia or Alzheimer's disease.
Key facts
- Who runs it
- Assistance Publique - Hôpitaux de Paris
- Where
- Paris, FranceSee the site
- Trial code
- Registry title
- Links Between Self-awareness and Sociocognitive Processes in Neurodegenerative Diseases
- Status
- Recruiting
- People taking part
- 34 people, planned
- Started
- Apr 2026
- Expected to end
- Dec 2027
- Type of study
- Observational, 2 groups
- Treatments tested
- Computer-based facial expression recognition task
- Computerized affective task
- UCLA Structured Insight Interview
- Barber's Standardized Suggestibility Scale
- Record updated
- 15 April 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for people aged 50-80 with behavioral variant frontotemporal dementia or Alzheimer's disease. They do computer tasks about emotions and self-awareness.
- Age
- 50 to 80 years
- Sex
- All sexes can join.
- Disease stage
- Possible or probable behavioral variant frontotemporal dementia, or Alzheimer's disease diagnosed with biomarkers. MMSE score of 20 or more.
- Biomarker or test result
- For Alzheimer's disease, the diagnosis must include biomarkers.
Main reasons for not taking part
- Moderate to severe language disorders (naming scale DO 40 of 32 or less)
- Cannot do computer tasks, in the investigator's opinion
- Other brain diseases such as epilepsy, Lewy body disease or vascular dementia
- Bipolar disorder, schizophrenia or a current major depressive episode
- Uncorrected vision problems
The registry criteria, word for word
Show all 10 criteriaShow less
Who can take part
- Diagnosis of possible or probable behavioral variant frontotemporal dementia according to the Rascovsky 2011 criteria (DLFTvc group) OR
- Diagnosis of Alzheimer's disease according to the Jack 2018 criteria, including biomarkers (MA group)
- Mini-Mental State Examination (MMSE) ≥ 20
- Age: 50-80 years
- Sufficient reading and writing proficiency in French to enable completion of the study procedures, in the investigator's opinion
Who cannot take part
- Moderate to severe language disorders: Confrontation naming (DO 40 scale) ≤ 32
- Other neurological disorders (including epilepsy, Lewy body disease, vascular dementia)
- Psychiatric comorbidities (bipolar disorder, schizophrenia, current major depressive episode)
- Uncorrected visual impairment
- Inability to perform computerized tasks according to the investigator's opinion
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 50 and 80 years old?
Where in France
- Cognitive Neurology Center, Lariboisière-Fernand Widal Hospital Group, APHPParis, FranceContact: Emmanuel Cognat, MD PhDTaking people
About the trial
What the trial wants to find out
This monocentric, non-interventional study (SELFSOC) investigates the relationship between self-awareness and social cognition in patients with behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD).
Read full original descriptionShow less
The primary objective is to assess metacognitive efficiency related to social cognitive performance using a computerized facial emotion recognition task combined with confidence judgments. Metacognitive indices (including Mratio) will quantify the correspondence between subjective and objective performance.
Thirty-four participants (17 bvFTD, 17 AD; age 50-80; MMSE ≥20) will complete two study visits involving tasks assessing emotion recognition, theory of mind, and memory.
The 2 groups in the trial
- Behavioral Variant Frontotemporal Dementia (bvFTD)
Participants diagnosed with behavioral variant frontotemporal dementia according to established clinical criteria (Rascovsky et al., 2011). Patients are aged 50-80 years with mild to moderate disease severity (MMSE ≥20).
Treatment: Computer-based facial expression recognition task, Computerized affective task, UCLA Structured Insight Interview, and Barber's Standardized Suggestibility Scale
- Alzheimer's Disease (AD)
Participants diagnosed with Alzheimer's disease based on biomarker-supported criteria (A+T+; Jack et al., 2018). Patients are aged 50-80 years with mild to moderate disease severity (MMSE ≥20).
Treatment: Computer-based facial expression recognition task, Computerized affective task, UCLA Structured Insight Interview, and Barber's Standardized Suggestibility Scale
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Study of the Links Between Self-awareness and Sociocognitive Processes in Neurodegenerative Diseases in People With Frontotemporal Lobar Degeneration, Behavioral Variant and Alzheimer's Disease
- Plain-language title
- How self-awareness relates to social understanding in frontotemporal dementia and Alzheimer's diseaseGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT07531732, who can take part
- Record updated
- 15 April 2026