Frontlight ResearchEarly access
Taking people in United StatesPhase 2/3
A Phase 2/3 Study of Brepocitinib in Adults With Lichen Planopilaris
Key facts
- Who runs it
- Priovant Therapeutics, Inc.
- Where
- Ann Arbor, Austin, Birmingham, Boston, Burlington, Cedar Park, Charleston, Chicago, Clarksville, Cleveland, Columbus, Denver, Durham, Farmington, Indianapolis, Irvine, Kansas City, Leawood, Lebanon, Lee's Summit, Louisville, Medina, Miami, Mill Creek, Minneapolis, Murfreesboro, Murray, New Haven, New Hyde Park, New York, Norfolk, Oakland, Philadelphia, Phoenix, Portland, Prosper, Richmond, Roanoke, Sacramento, San Francisco, Scottsdale, Skokie, Smyrna, and Tyler, United StatesSee the 44 sitesAlso in 3 other countries, 12 sites
- Trial code
- Status
- Recruiting
- Phase
- Phase 2/3
- People taking part
- 342 people, planned
- Started
- 19 Mar 2026
- Expected to end
- 31 Jul 2029
- Type of study
- Interventional, 2 groupsOne group gets a placebo (a dummy treatment), for comparison.
- Treatments tested
- Oral Brepocitinib
- Placebo
- Record updated
- 8 July 2026
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 8 criteriaShow less
Who can take part
- Age ≥ 18 years
- Scalp biopsy consistent with LPP
- Active and symptomatic LPP at screening and baseline-
- Weight > 40 kg to < 130 kg with BMI ≤ 45 kg/m2
Who cannot take part
- History of: Lymphoproliferative disorder; Active malignancy; History of cancer within 5 years prior to baseline (exceptions for basal cell carcinoma, squamous cell carcinoma, ductal carcinoma in situ of the breast, carcinoma in situ of the uterine cervix, or thyroid cancer)
- High risk of thrombosis or cardiovascular disease
- Active or recent infection
- High risk of herpes zoster
Where in United States
Also in 3 other countries, 12 sites
- Ann Arbor, MichiganHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Austin, TexasHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Birmingham, AlabamaHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Boston, MassachusettsHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Burlington, MassachusettsHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Cedar Park, TexasHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Charleston, South CarolinaHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Chicago, IllinoisHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Clarksville, IndianaHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Cleveland, OhioHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Columbus, OhioHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Denver, ColoradoHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Durham, North CarolinaHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Farmington, New MexicoHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Indianapolis, IndianaHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Irvine, CaliforniaHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Kansas City, MissouriHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Leawood, KansasHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Lebanon, New HampshireHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Lee's Summit, MissouriHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Louisville, KentuckyHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Medina, MinnesotaHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Miami, FloridaHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Mill Creek, WashingtonHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Minneapolis, MinnesotaHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Murfreesboro, TennesseeHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Murray, UtahHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- New Haven, ConnecticutHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- New Hyde Park, New YorkHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- New YorkHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Norfolk, VirginiaHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Oakland, CaliforniaHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Philadelphia, PennsylvaniaHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Phoenix, ArizonaHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Portland, OregonHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Prosper, TexasHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Richmond, VirginiaHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Roanoke, VirginiaHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Sacramento, CaliforniaHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- San Francisco, CaliforniaHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Scottsdale, ArizonaHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Skokie, IllinoisHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Smyrna, TennesseeHospital not named in the registryContact: Clinical Trial AdministratorTaking people
- Tyler, TexasHospital not named in the registryContact: Clinical Trial AdministratorTaking people
About the trial
What the trial wants to find out
This study will evaluate the clinical safety and efficacy of oral brepocitinib in participants with lichen planopilaris
The 2 groups in the trial
- Brepocitinib Dose Level 1Treatment being tested
Treatment: Oral Brepocitinib
- PlaceboPlacebo, for comparison
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- A Phase 2/3 Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Safety and Efficacy of Oral Brepocitinib in Adults With Lichen Planopilaris
- Record updated
- 8 July 2026