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Two knee insert types in robotic knee replacement for knee osteoarthritis

Compares two knee implant insert types in people having robotic knee replacement for osteoarthritis.

Key facts

Who runs it
Singapore General Hospital
Where
Singapore, SingaporeSee the site
Trial code
Registry title
Patient Outcomes Following Kinematic and Functional Alignment in Robotic-Assisted Total Knee Arthroplasty With Randomized Insert Types
Status
Recruiting
People taking part
240 people, planned
Started
14 Oct 2025
Expected to end
14 Oct 2027
Type of study
Interventional, 4 groups
Treatments tested
  • Medial Stabilized Insert
  • Cruciate Retaining Insert
Record updated
21 April 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with knee osteoarthritis who are having a robot-assisted total knee replacement with the VELYS system. People are randomly given one of two insert types.

Age
18 years and older
Sex
All sexes
Disease stage
Knee osteoarthritis (wear-and-tear arthritis of the knee) that needs surgery
Earlier treatment
People having a repeat (revision) knee replacement cannot join.

Main reasons for not taking part

  • Repeat (revision) knee replacement surgery
  • An active infection
  • Not able to come to follow-up visits
  • Severe other illnesses that may affect the surgery or taking part

The registry criteria, word for word

Show all 9 criteriaShow less

Other criteria

  • *Inclusion Criteria:*
  • Patients undergoing robotic-assisted total knee arthroplasty using the VELYS system
  • Diagnosis of knee osteoarthritis requiring surgical intervention
  • Able to provide informed consent
  • Willing to complete patient-reported outcome measures; **Exclusion Criteria:**
  • Patients undergoing revision knee arthroplasty
  • Presence of active infection
  • Inability to comply with follow-up assessments
  • Severe co-morbidities that may affect surgical outcomes or participation in the study

Where in Singapore

  • Singapore General HospitalSingapore, SingaporeContact: Clinical Research CoordinatorTaking people

About the trial

What the trial wants to find out

This study aims to evaluate patient outcomes following robotic-assisted total knee arthroplasty using the VELYS system. Patients undergoing surgery will receive either kinematic alignment or functional alignment as determined by the operating surgeon as part of routine clinical care. Within each surgical technique group, patients will be randomly assigned to receive different implant insert types (medial stabilised or cruciate retaining) using a REDCap-based randomisation process. Patient-reported outcome measures will be collected before surgery and at follow-up time points after surgery to assess clinical outcomes.

The 4 groups in the trial

  • Kinematic Alignment + Medial Stabilized InsertTreatment being tested

    Patients undergoing kinematic alignment with medial stabilised insert in robotic-assisted total knee arthroplasty.

    Treatment: Medial Stabilized Insert

  • Kinematic Alignment + Cruciate Retaining InsertTreatment being tested

    Patients undergoing kinematic alignment with cruciate retaining insert in robotic-assisted total knee arthroplasty

    Treatment: Cruciate Retaining Insert

  • Functional Alignment + Medial Stabilized InsertTreatment being tested

    Patients undergoing functional alignment with medial stabilised insert in robotic-assisted total knee arthroplasty.

    Treatment: Medial Stabilized Insert

  • Functional Alignment + Cruciate Retaining InsertTreatment being tested

    Patients undergoing functional alignment with cruciate retaining insert in robotic-assisted total knee arthroplasty

    Treatment: Cruciate Retaining Insert

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

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Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
A Prospective Randomized Controlled Trial Comparing Patient Outcomes Following Kinematic and Functional Alignment in Robotic-Assisted Total Knee Arthroplasty Using the VELYS System
Plain-language title
Two knee insert types in robotic knee replacement for knee osteoarthritisGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 14 November 2026.
Record updated
21 April 2026