Neural Mobilization vs Cervical Neuromodulation in DPN
Key facts
- Who runs it
- Abeer Abdrabo
- Where
- Egypt1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 75 people enrolled
- Started
- 5 Feb 2026
- Ended
- 30 May 2026
- Type of study
- Interventional, 3 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Manual Neural Mobilization
- Cervical Neuromodulatory Intervention
- Standard Care
- Record updated
- 29 September 2026
Who can take part
- Age
- 18 years to 65 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
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Who can take part
- Clinically confirmed diabetic peripheral neuropathy
- Ability to attend twice-weekly intervention sessions for 12 weeks
- Stable medication regimen for at least 3 months
Who cannot take part
- Recent surgery (<6 months) in lower limbs or cervical spine
- Severe cardiovascular, neurological, or musculoskeletal disorders
- Cognitive impairment preventing informed consent or compliance
- Pregnancy or breastfeeding
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
This study is a three-arm, assessor-blinded, randomized controlled pilot feasibility trial. The primary goal is to evaluate the feasibility and acceptability of conducting a full-scale randomized controlled trial (RCT) comparing two manual therapy techniques: Manual Neural Mobilization (MNM) and Cervical Neuromodulatory Intervention (CNI) in individuals with Diabetic Peripheral Neuropathy (DPN).
Read full original descriptionShow less
While glycemic control is a central part of managing type 2 diabetes, this study explores whether non-pharmacological manual therapies can serve as adjunctive interventions to improve metabolic outcomes. A total of 75 participants were assigned to either MNM, CNI, or standard care for 12 weeks. The study focuses on recruitment rates, adherence, and safety, while also exploring secondary outcomes like blood glucose levels (HbA1c, FBG) .
The 3 groups in the trial
- Manual Neural Mobilization (MNM)Treatment being tested
Participants in this group received manual neural mobilization techniques targeting the peripheral nerves of the lower limb. The intervention was administered twice weekly for 12 weeks in addition to standard care.
Treatment: Manual Neural Mobilization
- Cervical Neuromodulatory Intervention (CNI)Treatment being tested
Participants in this group received cervical neuromodulatory intervention aimed at influencing neural function via cervical spine techniques. The intervention was delivered twice weekly for 12 weeks in addition to standard care.
Treatment: Cervical Neuromodulatory Intervention
- Standard CareExisting treatment, for comparison
Participants in this group received standard medical and physiotherapy care without additional manual therapy interventions over a 12-week period.
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Manual Neural Mobilization Versus Cervical Neuromodulatory Intervention for Glycemic Control in Adults With Diabetic Peripheral Neuropathy: Pilot RCT - Hypothesis-generating Study
- Record updated
- 29 September 2026