Comparing Molecules Linked to Loose Lens Support in Angle-Closure Glaucoma
Compares molecules in people with angle-closure glaucoma who have loose lens support and those without.
Plain-language title generated from the registry record
Registry title: The Multi-Omics Analysis of Lens Zonule Relaxation in The PACG Pathogenesis
Key facts
- Where
- Wuhan, ChinaSee the site
Where in China
- Zhongnan Hospital of Wuhan UniversityWuhan, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Zhongnan Hospital
- Trial code
- NCT07539675
- Record updated
- 20 April 2026
- Original description
Compared with primary angle-closure glaucoma (PACG) patients without zonular laxity and the control group, there are differentially expressed molecules in PACG patients with zonular laxity, and a potential mechanistic network can be constructed therefrom.Read full original descriptionShow less
The Multi-Omics Analysis of Lens Zonule Relaxation in The PACG Pathogenesis
Compared with primary angle-closure glaucoma (PACG) patients without zonular laxity and the control group, there are differentially expressed molecules in PACG patients with zonular laxity, and a potential mechanistic network can be constructed therefrom.
Inclusion: Clinically diagnosed with primary angle-closure glaucoma (PACG); Aged ≥ 50 years, no gender restriction; Case Group A: Undergoing glaucoma surgery with intraoperatively confirmed significant zonular laxity; Case Group B: Undergoing glaucoma surgery with intraoperatively confirmed normal zonular morphology; Control group: age- and sex-matched with case groups; clinically diagnosed with age-related cataract; normal anterior chamber depth and angle; no history or signs of glaucoma; undergoing cataract surgery.
Exclusion: History of previous intraocular surgery; Long-term use of medications affecting connective tissue metabolism; Systemic diseases that can cause abnormal ocular zonules; Other severe ocular diseases; Secondary glaucoma.