Comparison of Propofol and Propofol-Ketamine Anesthesia on Optic Nerve Sheath Diameter in Endovascular Cerebral Aneurysm Procedures
Key facts
- Who runs it
- Ankara City Hospital Bilkent
- Where
- Türkiye1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 46 people enrolled
- Started
- 15 Jun 2025
- Ended
- 1 Jan 2026
- Type of study
- Observational, 2 groups
- Treatments tested
- Propofol (Astra-Zeneca)
- Propofol and Ketamine Mixture (Ketofol)
- Record updated
- 21 April 2026
Who can take part
- Age
- 18 years to 75 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 13 criteriaShow less
Who can take part
- Age between 18 and 75 years
- Patients scheduled for elective endovascular treatment of unruptured intracranial aneurysms
- ASA physical status I-III
- Glasgow Coma Scale score of 15
- Ability to read and write and provide written informed consent
Who cannot take part
- History of ocular disease or previous eye surgery
- Emergency surgical indication
- Coronary artery disease
- Psychiatric or neurological disorders interfering with consent or assessment
- Age under 18 or over 75 years
- ASA physical status IV or higher
- Presence of giant aneurysm
- Increased intracranial pressure
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
This study aimed to compare the effects of propofol-based anesthesia and propofol-ketamine anesthesia on optic nerve sheath diameter (ONSD) in patients undergoing elective endovascular treatment of unruptured intracranial aneurysms. ONSD, measured using ultrasonography, is a non-invasive surrogate marker of intracranial pressure. In addition, intraoperative hemodynamic parameters, cerebral oxygenation, and anesthetic requirements were evaluated to assess the safety and physiological impact of the two anesthesia techniques.
The 2 groups in the trial
- Propofol Anesthesia
Patients who underwent elective endovascular treatment of unruptured intracranial aneurysms under propofol-based general anesthesia
Treatment: Propofol (Astra-Zeneca)
- Propofol-Ketamine Anesthesia
Patients who underwent elective endovascular treatment of unruptured intracranial aneurysms under general anesthesia with a combination of propofol and ketamine
Treatment: Propofol and Ketamine Mixture (Ketofol)
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Publications
- Record updated
- 21 April 2026