Personalized Therapy of Long-term Low FODMAP in IBS Treatment: Role of Mobile Application and "Microbiota-gut-brain" Axis
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Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 20 and 65 years old?
Source: NCT07543354, who can take part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Taipei Veterans General Hospital, Taiwan
- Trial code
- NCT07543354
- Record updated
- 15 May 2026
- Original description
The purpose of this study is to evaluate the effectiveness of a mobile application (app) in helping clinicians and dietitians provide personalized low-FODMAP diet (LFD) therapy for patients with Irritable Bowel Syndrome (IBS). The study also aims to explore the potential biological mechanisms behind the clinical outcomes of this dietary intervention.Read full original descriptionShow less
The purpose of this study is to evaluate the effectiveness of a mobile application (app) in helping clinicians and dietitians provide personalized low-FODMAP diet (LFD) therapy for patients with Irritable Bowel Syndrome (IBS). The study also aims to explore the potential biological mechanisms behind the clinical outcomes of this dietary intervention.
Participants diagnosed with IBS will be recruited and screened through clinical questionnaires. Eligible participants will receive dietary education from a dietitian and be randomly assigned to one of two groups: the AI-assisted LFDapp group or the LFD booklet group.
The study consists of three main phases:
Initial Intervention (4-6 weeks): Participants will follow their assigned diet intervention and complete assessments regarding gastrointestinal symptoms, psychological traits (such as anxiety and depression), and quality of life.
Reintroduction Phase (12 weeks): Participants who respond well to the diet will enter a phase where specific foods are gradually reintroduced.
Personalization \& Follow-up (4 weeks): A personalized diet will be established, followed by a final evaluation of bowel function and mental well-being.
Researchers will use various standardized questionnaire to track changes in symptoms and overall well-being throughout the study period.
Inclusion: Participants aged between 20 and 65 years; Diagnosed with Irritable Bowel Syndrome (IBS); Overall IBS symptoms remain unresolved or active at the time of enrollment.
Exclusion: Major psychiatric disorders, including patients with significant anxiety or depression currently requiring treatment with anti-anxiety or anti-depressant medications; Use of antibiotics or analgesics within 90 days prior to enrollment; Newly initiated use of probiotics or prebiotics within 90 days prior to enrollment; Current use of antipsychotic medications, antidiarrheal agents, probiotics, or analgesics; History of Inflammatory Bowel Disease (IBD); Active infection within the past 90 days; History of thyroid disease; History of epilepsy; History of stroke, cerebral hemorrhage, or other central nervous system diseases; Significant renal, hepatic, or major cardiovascular diseases; Malignant diseases (cancer); Type 2 diabetes; Other chronic pain conditions; History of abdominal surgery (excluding cholecystectomy or appendectomy) or any history of brain surgery; Inability to understand the study procedures or provide written informed consent; Currently pregnant; Appendectomy or cholecystectomy performed within the past year; Currently participating in other clinical trials.