Testing how different exercise types affect inflammation in adults with obesity
Compares moderate, vigorous and short maximal exercise on inflammation in adults with obesity.
Plain-language title generated from the registry record
Registry title: The ISAR InflEx Trial (Inflammation and Exercise)
Key facts
- Where
- München, GermanySee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 45 years old?
Source: NCT07543666, who can take part
Where in Germany
- German Heart CentreMünchen, GermanyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Department of Cardiology German Heart Center Munich TUM University Hospital
- Trial code
- NCT07543666
- Record updated
- 24 April 2026
- Original description
A sedentary lifestyle and obesity are associated with chronic low-grade inflammation and an elevated risk of cardiovascular disease (CVD). This study aims to systematically characterize and compare the effects of three distinct exercise modalities - moderate-intensity, vigorous-intensity, and short-duration maximal exercise - each differing in duration and intensity, on systemic inflammation and immune function. The study investigates the potential of exercise as an effective anti-inflammatory intervention for the prevention of CVD.Read full original descriptionShow less
Impact of Different Exercise Intensities and Durations on Systemic Inflammation - The ISAR InflEx Trial (Inflammation and Exercise) -
A sedentary lifestyle and obesity are associated with chronic low-grade inflammation and an elevated risk of cardiovascular disease (CVD). This study aims to systematically characterize and compare the effects of three distinct exercise modalities - moderate-intensity, vigorous-intensity, and short-duration maximal exercise - each differing in duration and intensity, on systemic inflammation and immune function. The study investigates the potential of exercise as an effective anti-inflammatory intervention for the prevention of CVD.
Inclusion: BMI 25.0 - 30.0 kg/m²; age 18 - 45 years; informed consent; no regular physical activity (≤1x/week of structured exercise); willingness to strictly follow and adhere to the intervention protocol for the entire study.
Exclusion: Regular use of medication; any acute or chronic illness; pregnancy and breastfeeding; active smoking.