Testing new CT scanners to detect reduced heart blood flow in coronary artery disease
Tests new CT scanners to find blocked heart arteries in adults.
Plain-language title generated from the registry record
Registry title: Spectral and Ultra High Resolution CT Systems for Non-Invasive Detection of Myocardial Ischemia: Stress CT Perfusion VS. FFR-CT
Key facts
- Where
- Milan and Roma, ItalySee the 2 sites
Where in Italy
- IRCCS Ospedale San RaffaeleMilan, ItalyNo longer taking part
- Azienda Ospedaliero-Universitaria Sant'AndreaRoma, ItalyNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- IRCCS San Raffaele
- Trial code
- NCT07544277
- Record updated
- 21 September 2026
- Original description
Coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide. Coronary Computed Tomography angiography (CCTA) gained a pivotal clinical role for excellent sensitivity in rule-out CAD, but has limited specificity for a tendency to overestimate stenoses and for the lack of information about their hemodynamic impact. Fractional Flow Reserve derived from CT (FFR-CT) and stress CT perfusion (CTP) have been recently proposed to complement CCTA in the non-invasive assessment of myocardial ischemia, increasing the specificity and avoiding unnecessary catheterization. However, on energy-integrating (EID)-CT, FFR-CT has suboptimal performance, while CTP is affected by high radiation exposure. Both these approaches may benefit by the introduction of the new Photon Counting Detector (PCD)-CT technology, but data completely lacks. Aim of the study is to assess the performance of PCD-CT in the identification of significant CAD combining CCTA with FFR-CT and spectral CTP.Read full original descriptionShow less
Spectral and Ultra High Resolution CT Systems for Non-Invasive Detection of Myocardial Ischemia: Stress CT Perfusion VS. FFR-CT
Coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide. Coronary Computed Tomography angiography (CCTA) gained a pivotal clinical role for excellent sensitivity in rule-out CAD, but has limited specificity for a tendency to overestimate stenoses and for the lack of information about their hemodynamic impact. Fractional Flow Reserve derived from CT (FFR-CT) and stress CT perfusion (CTP) have been recently proposed to complement CCTA in the non-invasive assessment of myocardial ischemia, increasing the specificity and avoiding unnecessary catheterization. However, on energy-integrating (EID)-CT, FFR-CT has suboptimal performance, while CTP is affected by high radiation exposure. Both these approaches may benefit by the introduction of the new Photon Counting Detector (PCD)-CT technology, but data completely lacks. Aim of the study is to assess the performance of PCD-CT in the identification of significant CAD combining CCTA with FFR-CT and spectral CTP.
Inclusion: Patient referred to our hospitals for elective CCTA for ruling out CAD; CCTA evidence of moderate stenosis (50-69%) requiring functional assessment according to ESC guidelines.
Exclusion: previous revascularization,; hemodynamically unstable conditions,; myocardial infarction,; atrial fibrillation or other significant arrhythmias; and; other overt cardiovascular diseases affecting CTP performance (e.g., heart failure, severe valvular regurgitation),; renal insufficiency (GFR<30 mL/min),; obesity (BMI>40 kg/m2),; pregnancy and breastfeeding,; contraindications to iodinated contrast agents or regadenoson.