Tests ways to clean infected tooth root canals in adults with type 2 diabetes
Compares laser, vinegar and herbal treatments for cleaning infected root canals.
Plain-language title generated from the registry record
Registry title: Effect of Diode Laser, Gudmar and Vinegar in Diabetic Patients During Root Canal Treatment
Key facts
- Where
- Noida, IndiaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with type 2 diabetes who have a root canal infection in a tooth with a lesion at the root tip.
- Age
- 25 to 60 years
- Sex
- Men and women can join.
- Disease stage
- Type 2 diabetes with HbA1c of 6.5% (48 mmol/mol) or higher. Primary root canal infection in a multirooted tooth, with a lesion at the root tip seen on X-ray.
- Earlier treatment
- No antibiotics in the previous three months.
- Biomarker or test result
- Fasting blood sugar of 126 mg/dl (7 mmol/L), random blood sugar under 200 mg/dl (11.1 mmol/L), and HbA1c of 6.5% (48 mmol/mol) or higher.
Main reasons for not taking part
- Other health conditions besides type 2 diabetes
- Pregnancy
- Antibiotics in the previous three months
- Teeth with developmental defects, calcified canals or twisting canals
- Teeth that cannot be isolated with a rubber dam, or fractured roots
Read by machine on 13 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 25 and 60 years old?
Source: NCT07549373, who can take part
Where in India
- Dr Lakshmi PandeyNoida, IndiaContact: Lakshmi PandeyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Sharda University
- Trial code
- NCT07549373
- Record updated
- 28 May 2026
- Original description
MethodologyRead full original descriptionShow less
Antibacterial Effect Of 940nm Diode Laser, Apple Cider Vinegar And Gymnema Sylvestre In Diabetic Patients With Apical Periodontitis Against Peptostreptococcus Species- A Randomized Clinical Trial
Methodology
Patient with diabetes 2 with informed consent -convenience sampling over a one year period.The tooth isolated with a rubber dam and the correct disinfection procedures will be used. researcher will do the Access preparation Working length -electronic apex locator (Dentsply Propex II) as well as a radiographic approach.
After the canals will be obturated using ZOE sealer and gutta percha and post endodontic restoration is done using composite restoration. Patient is kept on follow up for 7days, 15 days, 30 days ,45 days and 60 days Clinical outcome is measure using periapical radiograph (RVG) Pain is measured using visual analog scale to mark the pain intensity. Data will be analysed statistically To enlarge the root canals (ISO size 20 file)
A sterile paper point inside the root canal for one minute until the apex of the root canal is reached
Using T.E Buffer, samples will be delivered to the School Of Basic Life Sciences, Sharda University.
The samples will be subjected to traditional PCR analysis for the detection of Peptostreptococcus spp. in the root canal.
Grouping Following instrumentation, 5% NaOCl and 17% EDTA irrigation will be done. Control group (n=15) The final irrigant will be saline Group 1 (n=15) Irrigation using 5% apple cider vinegar done The final irrigant will be saline Group 2 (n=15) Diode laser is used for disinfection in the presence of saline Group 3 (n=15) Gymnema Sylvestre Mother Tincture Q 1000 CH solution is used for disinfection in the presence of saline Group 4 (n=15) Diode laser is used for disinfection in the presence of 5% apple cider vinegar. The final irrigant will be saline Group 5 (n=15) Diode laser is used for disinfection in the presence of Gymnema Sylvestre Mother Tincture Q 1000 CH solution. The final irrigant will be saline
After cleaning and shaping, samples will be collected and sent through T.E. Buffer to the School Of Basic Life Sciences, Sharda University.
The samples will be subjected to traditional PCR analysis for the detection of Peptostreptococcus spp. in the root canal.
Inclusion: Using radiographs, intraoral periapical radiographs (RVG) primary endodontic infection will be selected; Multirooted teeth , root with periapical lesion will be selected; Type 2 diabetics between the ages of 25 years and 60 years will be chosen; both male and female patients; A fasting blood sugar level of 126 mg/dl and a random blood sugar level of less than 200 mg/dl; HbA1c (glycated haemoglobin) ≥ 6.5%.
Exclusion: Those patients that have used antibiotics within the previous three months,; Patients with systemic conditions other than type 2 diabetes; Women who are pregnant; Those patients that have teeth with developmental defects, calcified canals,; Teeth that cannot be isolated with rubber dams,; Tortuous canals; Roots that are fractured.