Following people with stroke through every stage of care in Germany
Follows people with stroke from first care to recovery and follow-up.
Plain-language title generated from the registry record
Registry title: Master Study Protocol for the Cohort of the Specialist Network Stroke (SN Stroke)(Stroke-CORE)
Key facts
- Where
- Berlin, Bielefeld, Dresden, Erlangen, Essen, Hamburg, Heidelberg, Leipzig, Lübeck, München, Tübingen, and Würzburg, GermanySee the 12 sites
Where in Germany
- Charité University, Berlin, GermanyBerlin, GermanyNo longer taking part
- Universität Bielefeld, Universitätsklinikum OWL, Evangelisches Klinikum Bethel gGmbH,Bielefeld, GermanyNo longer taking part
- Universitätsklinikum Carl Gustav Carus DresdenDresden, GermanyNo longer taking part
- Universitätsklinikum ErlangenErlangen, GermanyNo longer taking part
- Universitätsklinikum EssenEssen, GermanyNo longer taking part
- Universitatsklinikum Hamburg-Eppendorf (UKE)Hamburg, GermanyNo longer taking part
- Universitätsklinikum HeidelbergHeidelberg, GermanyNo longer taking part
- Universitatsklinikum LeipzigLeipzig, GermanyNo longer taking part
- Universitätsklinikum Schleswig-Holstein (UKSH), Campus LübeckLübeck, GermanyNo longer taking part
- Ludwig Maximilians Universität KlinikumMünchen, GermanyNo longer taking part
- Universitätsklinikum TübingenTübingen, GermanyNo longer taking part
- Universitätsklinikum WürzburgWürzburg, GermanyNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Charite University, Berlin, Germany
- Trial code
- NCT07553650
- Record updated
- 9 July 2026
- Original description
The Stroke-CORE cohort aims to provide a comprehensive and up-to-date understanding of stroke care in Germany. To achieve this, patients are followed along the entire continuum of care-from initial management before hospital admission, through acute treatment, rehabilitation, and follow-up care, to the prevention of recurrent strokes. Strokes occurring in childhood are also included in this cohort study.Read full original descriptionShow less
Master Study Protocol for the Cohort of the Specialist Network Stroke (SN Stroke) (Stroke-CORE)
The Stroke-CORE cohort aims to provide a comprehensive and up-to-date understanding of stroke care in Germany. To achieve this, patients are followed along the entire continuum of care-from initial management before hospital admission, through acute treatment, rehabilitation, and follow-up care, to the prevention of recurrent strokes. Strokes occurring in childhood are also included in this cohort study.
In addition, the study seeks to establish effective structures for the early identification and inclusion of patients in clinical research (screening). In this context, structured screening processes are being implemented across all levels of care at participating sites within the Network University Medicine (NUM), a collaboration of German university hospitals. At the same time, the cohort serves as a platform within this network to systematically address open research questions in various areas of stroke care and to support the targeted planning and conduct of future clinical studies.
The study includes patients with ischemic stroke (caused by a blocked blood vessel) or intracerebral hemorrhage (bleeding within the brain). Participation takes place in different thematic modules, each focusing on specific aspects of the disease course and its management. These modules address, among other topics, acute hospital treatment, measures to prevent recurrent strokes (secondary prevention), possible complications, pre-hospital care, rehabilitation, follow-up care, and long-term outcomes such as physical recovery, independence in daily life, and cognitive functions including memory and concentration.
As part of the study, a range of data is collected. This includes sociodemographic information (such as age and living situation) as well as medical data, for example on prior conditions, diagnoses, treatments, and comorbidities. In addition, patients' health status is assessed at multiple time points in order to better understand the course of the disease. Depending on the level of participation, data collection may be complemented by the collection of biological samples, such as blood. These are obtained either during routine clinical procedures or through simple, minimally burdensome (non-invasive) methods.
The study is structured into several levels that differ in the scope and depth of data collection. The basic level includes essential information, while higher levels involve more detailed assessments. In addition, some levels include the collection of biological samples, and there are optional supplementary modules in which patients may participate voluntarily. This tiered approach allows participation to be flexibly adapted to the individual situation while contributing to a nuanced and comprehensive understanding of stroke care.
Inclusion: Diagnosis of AIS or ICH; the AIS diagnosis may be diagnosed clinically or radiologically (i.e., focal neurological impairment of sudden onset, lasting more than 24 hours and of presumed vascular origin, or with proof of cerebral ischaemia corresponding to the clinical symptoms in neuroimaging); for ICH diagnosis requires clinical symptoms and radiological diagnosis of ICH; Hospital admission <24h after symptom onset; Age 18+ years for the basic Modules AIS and ICH; age <18 years for the basic Module paediatric stroke patients; Informed consent: Signed IC from patients capable of giving consent and understanding all content of the IC or IC of an appropriate patient representative or deferred consent, if patients are unable to consent themselves; Additional inclusion criteria are defined by the individual Modules.
Exclusion: In-hospital stroke; Stroke as a complication of a medical procedure; Already enrolled in the SN STROKE base cohort; TIA; SAH; Enrolment in a randomised placebo-controlled interventional trial.