A Single-center, Prospective, Self-controlled, Observational Real-world Study of the Efficacy and Safety of Anti-IL-17A/F Monoclonal Antibody Combined With Non-ablative Dot Laser for the Treatment of Mild to Moderate Hidradenitis Suppurativa
Key facts
- Where
- Hangzhou, ChinaSee the site
- Phase
- Phase 4
Where in China
- 2nd Affiliated Hospital, School of Medicine, Zhejiang University, ChinaHangzhou, ChinaContact: Jiaqi ChenNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Second Affiliated Hospital, Zhejiang University, School of Medicine
- Trial code
- NCT07554014
- Record updated
- 28 April 2026
- Original description
The goal of this clinical trial is to learn if combining an IL-17A/F monoclonal antibody with non-ablative fractional laser therapy works and is safe in patients with mild to moderate hidradenitis suppurativa (HS). The main questions it aims to answer are:Read full original descriptionShow less
The goal of this clinical trial is to learn if combining an IL-17A/F monoclonal antibody with non-ablative fractional laser therapy works and is safe in patients with mild to moderate hidradenitis suppurativa (HS). The main questions it aims to answer are:
Does the combination treatment reduce HS symptoms compared to before treatment? What are the main side effects of this combination treatment? Researchers will compare how participants feel and look after treatment to their own condition before treatment.
Participants will:
Get the combined treatment once every 4 weeks for 16 weeks Give skin and blood samples before the first treatment and at the last treatment visit Have a final check-up 8 weeks after the last treatment
Inclusion: Patients voluntarily participate in the study and sign the informed consent form; Male or female participants aged ≥ 18 years (at the time of signing the informed consent form); Patients with mild to moderate hidradenitis suppurativa: Hurley stage I or II; Participants have stable disease at screening and baseline, with lesions in ≥ 1 anatomical region and a total abscess and inflammatory nodule (AN) count ≥ 3; Participants must have intolerance, contraindication, or inadequate response to oral antibiotic treatment for HS for at least 3 months, or have relapsed after stopping such treatment; Have a basic understanding of the study purpose, the intervention, and possible side effects, and voluntarily sign the informed consent form in accordance with the spirit of the Declaration of Helsinki; Agree to receive regular treatment, attend follow-up visits, and undergo the required examinations and tests as specified in the clinical study protocol.
Exclusion: Prior use of biologics or small molecule targeted agents; Systemic use of corticosteroids within the past 4 weeks, or topical use within the past 2 weeks; Known allergy to the study drug or its excipients; Presence of tunnels on ultrasound at baseline; diagnosed with inflammatory diseases other than HS; history of chronic or recurrent infections; history of malignancy; History of drug abuse, suicide attempt, or psychiatric disorders; Any other condition that, in the opinion of the investigator, would make the participant unsuitable for inclusion; Participated in another clinical trial within the past 3 months; Pregnant or breastfeeding women, or those planning to become pregnant during the study period.