IOS Parameters and PAP Titration Pressure in Obstructive Sleep Apnea
Key facts
- Who runs it
- Mustafa Kemal University
- Where
- Türkiye1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Not yet recruiting
- People taking part
- 92 people, planned
- Started
- 1 May 2026
- Expected to end
- 2 Jan 2027
- Type of study
- Observational
- Record updated
- 28 April 2026
Who can take part
- Age
- 18 years to 80 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
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Who can take part
- Adults aged 18 to 80 years
- Diagnosed with obstructive sleep apnea (OSA) by overnight polysomnography (PSG)
- Apnea-hypopnea index (AHI) ≥ 15
- Undergoing positive airway pressure (PAP) titration (CPAP or BPAP)
- Able to perform impulse oscillometry (IOS) test
- Provided written informed consent
Who cannot take part
- Neuromuscular disease or restrictive lung disease
- Recent upper airway infection (< 2 weeks)
- Central sleep apnea
- Incomplete PSG or IOS data
- Inability to cooperate with testing procedures
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
This prospective observational study aims to investigate whether impulse oscillometry (IOS)-a non-invasive lung function test-can help predict the specific pressure settings needed for positive airway pressure (PAP) therapy in patients with obstructive sleep apnea (OSA).
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Currently, finding the optimal therapeutic pressure for OSA patients typically requires a titration process during sleep. This study explores if IOS parameters, which measure airway resistance and elasticity through small pressure oscillations during normal breathing, correlate with the final titration pressures (CPAP, EPAP, IPAP, and ΔP) determined by polysomnography.
Adult patients diagnosed with moderate-to-severe OSA (Apnea-Hypopnea Index ≥ 15) will undergo standard diagnostic sleep testing followed by IOS testing using the Vyaire Vyntus BodyBox® system. The researchers will evaluate whether these respiratory measurements can accurately predict required airway pressures and if they can help clinicians distinguish between patients who need Continuous Positive Airway Pressure (CPAP) versus Bilevel Positive Airway Pressure (BPAP) therapy.
The group in the trial
- Moderate-to-Severe OSA Patients
Adult patients newly diagnosed with moderate-to-severe obstructive sleep apnea (AHI ≥ 15) who are scheduled to undergo an overnight PAP titration polysomnography. All participants in this single cohort will receive baseline impulse oscillometry (IOS) testing prior to their sleep study.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Impulse Oscillometry for Prediction of PAP Titration Pressure in Obstructive Sleep Apnea (IOS-PAP Study)
- Fit questions
- Built from NCT07554430, who can take part
- Record updated
- 28 April 2026