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Comparing sleep measurements across several nights of home testing for obstructive sleep apnea

Looks at how sleep apnea measures change between nights in adults.

Key facts

Who runs it
Insel Gruppe AG, University Hospital Bern
Where
Switzerland1 site in 1 countryChoose a country to see its sites
Trial code
Registry title
Night-to-Night Variability of Novel Physiological Parameters in Home Sleep Apnea Testing
Status
Recruiting
People taking part
192 people, planned
Started
24 Jul 2026
Expected to end
30 Jun 2027
Type of study
Observational
Record updated
29 July 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with suspected or diagnosed sleep-disordered breathing, such as obstructive sleep apnea. Participants do sleep tests at home over several nights.

Age
18 years and older
Sex
All sexes
Disease stage
Suspected or diagnosed sleep-disordered breathing of any severity, as set by the German guidelines for home sleep apnea testing.
Earlier treatment
No active treatment during the sleep recordings or in the 2 weeks before, such as mandibular advancement devices or positive airway pressure therapy.

Main reasons for not taking part

  • Known or suspected neurological sleep disorder, such as narcolepsy or parasomnia
  • Known or suspected psychiatric sleep disorder
  • Known or suspected central or complex sleep apnea
  • Not able to do sleep measurements reliably, or not able to give consent
  • Not enough German, or shift work less than 2 weeks before testing

The registry criteria, word for word

Show all 11 criteriaShow less

Who can take part

  • Patients with suspected or diagnosed sleep-disordered breathing, irrespective of disease severity, as defined by the indications for home sleep apnea testing in the German guidelines [15]
  • No active treatment during sleep recordings or within preceding two weeks (e.g., mandibular advancement devices, positive airway pressure therapy)
  • Written informed consent obtained

Who cannot take part

  • Shift workers (with shift work <2 weeks before testing)
  • Known or suspected neurological sleep disorder (e.g., narcolepsy, parasomnia)
  • Known or suspected psychiatric sleep disorder
  • Age <18 years
  • Known or suspected central and complex sleep apnea
  • Participants who are unable to perform sleep measurements reliably
  • Insufficient knowledge of the project language (German)
  • Inability to give consent

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

Obstructive sleep apnea (OSA) is usually diagnosed from a single night of home sleep apnea testing using the apnea-hypopnea index (AHI). However, the AHI varies substantially from night to night, undermining diagnostic accuracy, and shows only modest correlation with symptoms. This variability further limits its usefulness for predicting cardiovascular and other complications. Besides the traditional AHI, more robust physiological markers are needed.

Read full original descriptionShow less

Several emerging physiological metrics - hypoxic burden, ventilatory burden, heart rate variability, autonomic arousals, and the pulse wave amplitude drop index - capture the physiological impact of OSA more comprehensively and demonstrate stronger associations with cardiovascular risk. Despite this promise, their night-to-night variability has not been studied.

A systematic evaluation of both established and novel OSA metrics across nights is essential to identify reliable, stable parameters suitable for clinical routine. This improves diagnostic precision beyond what traditional metrics can provide, enhances patient selection, reduces costs and patient harm, and may improve treatment outcomes.

The group in the trial

  • All participants

    Participants will undergo repeated sleep testing using respiratory polygraphy over 4 nights and oximetry over 10 nights, starting in parallel. Before and after the recordings they will fill out symptom questionnaires and patient-reported outcome measures.

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Night-to-Night Variability of Novel Physiological Parameters in Home Sleep Apnea Testing
Plain-language title
Comparing sleep measurements across several nights of home testing for obstructive sleep apneaGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 14 November 2026.
Record updated
29 July 2026