Gentle brain stimulation for movement and daily function in multiple sclerosis
Tests stimulation of the cerebellum against sham stimulation in adults with multiple sclerosis.
Plain-language title generated from the registry record
Registry title: Bilateral Anodal Cerebellar tDCS for Multidomain Dysfunctions in Patients With Multiple Sclerosis
Key facts
- Where
- Sharjah city, United Arab EmiratesSee the site
Where in United Arab Emirates
- University of SharjahSharjah city, United Arab EmiratesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Sharjah
- Trial code
- NCT07555379
- Record updated
- 29 April 2026
- Original description
The goal of this clinical trial is to learn if brain stimulation can improve movement and daily function in people with multiple sclerosis (MS). The study will also look at how this treatment affects fatigue, sleep, memory and attention, and quality of life.Read full original descriptionShow less
Bilateral Anodal Cerebellar tDCS for Multidomain Dysfunctions in Patients With Multiple Sclerosis: A Randomized Controlled Trial Study
The goal of this clinical trial is to learn if brain stimulation can improve movement and daily function in people with multiple sclerosis (MS). The study will also look at how this treatment affects fatigue, sleep, memory and attention, and quality of life.
The main questions this study aims to answer are the following:
Does this treatment improve coordination and balance? Does it reduce fatigue and improve sleep and daily life? Does it change brain activity?
Researchers will compare active brain stimulation to sham stimulation (a look-alike treatment that does not deliver real stimulation) to see if the treatment works.
Participants will:
Receive brain stimulation sessions for two weeks Attend assessment sessions before and after treatment Return for a follow-up visit after four weeks Complete tests of movement, fatigue, sleep, and thinking
Inclusion: Confirmed diagnosis of Multiple Sclerosis according to the revised McDonald criteria; Adult Age > 18 years; Expanded Disability Status Scale (EDSS) score between 2.0 and 6.0; Clinically stable disease status for at least 3 months prior to enrollment; On stable disease-modifying therapy (DMT) for at least 3 months; Ability to understand study procedures and provide informed consent; Ability to ambulate independently or with assistive devices sufficient to complete motor assessments.
Exclusion: Metallic implants in the head or skull incompatible with transcranial magnetic stimulation (TMS); History of epilepsy or seizures; Severe cognitive impairment preventing participation in assessments; Other neurological or psychiatric disorders that may confound study outcomes; Severe musculoskeletal or orthopedic conditions interfering with motor performance testing; Multiple sclerosis relapse within the past 3 months; Presence of implanted electronic devices (e.g., pacemaker, neurostimulator); Pregnancy or planned pregnancy during the study period; Contraindications to non-invasive brain stimulation or TMS.