Eye Movement Problems and Later Diagnosis of Multiple Sclerosis
Looks back at adults with internuclear ophthalmoplegia to see who later develops multiple sclerosis.
Plain-language title generated from the registry record
Registry title: Internuclear Ophthalmoplegia and Multiple Sclerosis: a Multicenter Retrospective Study
Key facts
- Where
- Strasbourg, FranceSee the site
Where in France
- Les Hôpitaux UniversitairesStrasbourg, FranceNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Hospital, Strasbourg, France
- Trial code
- NCT07560995
- Record updated
- 8 May 2026
- Original description
Internuclear ophthalmoplegia is a symptom frequently associated with multiple sclerosis (MS), although other etiologies are possible. Some patients do not meet the diagnostic criteria for MS at the time of the internuclear ophthalmoplegia episode but subsequently convert to MS. Studying this specific clinical situation may help enable earlier diagnosis of MS.Read full original descriptionShow less
Internuclear Ophthalmoplegia and Multiple Sclerosis: a Multicenter Retrospective Study
Internuclear ophthalmoplegia is a symptom frequently associated with multiple sclerosis (MS), although other etiologies are possible. Some patients do not meet the diagnostic criteria for MS at the time of the internuclear ophthalmoplegia episode but subsequently convert to MS. Studying this specific clinical situation may help enable earlier diagnosis of MS.
The objective is to analyze the proportion of patients with isolated internuclear ophthalmoplegia who convert to multiple sclerosis and to identify factors associated with this conversion.
The study hypothesis is that the presence of internuclear ophthalmoplegia is highly suggestive of multiple sclerosis, particularly when cerebrospinal fluid-specific oligoclonal bands are present.
Inclusion: Patients with internuclear ophthalmoplegia listed as a primary or associated diagnosis; Patients hospitalized in a neurology department.
Exclusion: Patients under 18 years of age.