Covered Stents Versus Bare Metal Stents for Narrowed Kidney Arteries Caused by Atherosclerosis
Compares two stent types in people with atherosclerotic renal artery stenosis.
Plain-language title generated from the registry record
Registry title: Covered vs Bare Metal Stents for Atherosclerotic Renal Artery Stenosis
Key facts
- Where
- Beijing, Chengdu, Chongqing, Dalian, Guangzhou, Harbin, Jilin City, Jinan, Nanchang, Nanjing, Qingdao, and Zhengzhou, ChinaSee the 15 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 80 years old?
Source: NCT07566065, who can take part
Where in China
- Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037Beijing, ChinaNo longer taking part
- The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of ChengduChengdu, ChinaNo longer taking part
- Department of Cardiovascular Medicine, Cardiovascular Research Center , The First Affiliated Hospital of Chongqing Medical UniversityChongqing, ChinaNo longer taking part
- Affilated Zhongshan Hospital of Dalian UniversityDalian, ChinaNo longer taking part
- Frist Aiffiliated Hospital of Dalian Medical UniversityDalian, ChinaNo longer taking part
- the First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou, ChinaNo longer taking part
- The Second Affiliated Hospital of Harbin Medical UniversityHarbin, ChinaNo longer taking part
- The Second Affiliated Hospital of Harbin Medical University, Ha'erbinHarbin, ChinaNo longer taking part
- China-Japan Union Hospital of Jilin University, Changchun, LilinJilin City, ChinaNo longer taking part
- Qilu Hospital of Shandong UniversityJinan, ChinaNo longer taking part
- Jiangxi Provincial People's Hospital (The First Affiliated Hospital of Nanchang Medical College)Nanchang, ChinaNo longer taking part
- Nanjing Pukou People's Hospital(Liangjiang Hospital Southeast University)Nanjing, ChinaNo longer taking part
- Qingdao Hospital University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital)Qingdao, ChinaNo longer taking part
- Fuwai Central China Cardiovascular HospitalZhengzhou, ChinaNo longer taking part
- Zhengzhou Central Hospital Affiliated to Zhengzhou UniversityZhengzhou, ChinaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Chinese Academy of Medical Sciences, Fuwai Hospital
- Trial code
- NCT07566065
- Record updated
- 4 May 2026
- Original description
Atherosclerotic renal artery stenosis is the most common cause of secondary hypertension , increasing the risk of cardiovascular and kidney-related complications. Some small-scale studies have suggested that covered stents are effective and safe, but high-quality evidence from large-scale studies in atherosclerotic renal artery stenosis remains limited.Read full original descriptionShow less
Endovascular Treatment of Atherosclerotic Renal Artery Stenosis: A Prospective Randomized Controlled Study Comparing Covered Stents and Bare Metal Stents
Atherosclerotic renal artery stenosis is the most common cause of secondary hypertension , increasing the risk of cardiovascular and kidney-related complications. Some small-scale studies have suggested that covered stents are effective and safe, but high-quality evidence from large-scale studies in atherosclerotic renal artery stenosis remains limited.
This study aims to evaluate whether covered stents are more effective than bare metal stents in patients with atherosclerotic renal artery stenosis. Eligible participants will be randomly assigned to receive either a covered stent or a bare metal stent. Patients will be followed for 12 months to assess Changes in eGFR, 24-hour systolic blood pressure, and 24-hour diastolic blood pressure from baseline to 12 months were compared among the groups.
The results of this study may help improve treatment strategies and guide the selection of stent type for patients with this condition.
Inclusion: 1) Renal artery diameter stenosis ≥60%; 2) Office systolic blood pressure ≥ 160 mmHg and/or office diastolic blood pressure ≥ 100 mmHg on at least two separate days without antihypertensive medication, or office systolic blood pressure ≥ 140 mmHg and/or office diastolic blood pressure ≥ 90 mmHg while on three antihypertensive drugs at conventional doses; 3) Serum creatinine < 264 μmol/L (3.0 mg/dL); 4) Affected kidney length ≥ 7.0 cm, with residual glomerular filtration rate (GFR) ≥ 10 mL/min.
Exclusion: 1) Unstable clinical condition rendering the patient intolerant to revascularisation therapy; 2) Urinary protein ≥2+; 3) Contrast medium allergy; 4) Renal artery anatomy unsuitable for revascularisation therapy; 5) Reference vessel diameter <3.5mm or >8mm. 6)Patients with non-atherosclerotic renal artery stenosis (such as fibromuscular dysplasia or Takayasu arteritis); 7)Reference vessel diameter < 3.5 mm or > 8 mm.