How Exercise Training Affects Insulin Response and Fitness in Type 1 Diabetes and Overweight
Tests an exercise program's effect on fitness and insulin response in type 1 diabetes.
Key facts
- Who runs it
- University of Virginia
- Where
- Charlottesville, United StatesSee the site
- Trial code
- Registry title
- Impact of Obesity on Microvascular Insulin Action and Cardiorespiratory Fitness in Type 1 Diabetes
- Status
- Recruiting
- People taking part
- 60 people, planned
- Started
- 23 Feb 2026
- Expected to end
- 30 Jun 2030
- Type of study
- Interventional, 4 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Exercise training
- Record updated
- 7 May 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 21 to 50 with type 1 diabetes, with or without obesity, and for healthy controls, to study fitness and insulin action before and after an exercise program.
- Age
- 21 to 50 years
- Sex
- Men and women can join.
- Disease stage
- For type 1 diabetes: disease for at least 5 years and HbA1c of 8.5% (69 mmol/mol) or lower, on multiple daily insulin injections or an insulin pump.
- Earlier treatment
- Non-insulin medicines must have been stable for over 6 months. Estrogen or progesterone medicines must be stopped at least 3 months before the study.
- Biomarker or test result
- Body mass index (BMI): 19 to 27 kg/m2 for controls and type 1 diabetes alone; 30 to 40 kg/m2 for those with obesity (27.5 to 37.5 for Asian Americans).
Main reasons for not taking part
- Other acute or chronic disease besides type 1 diabetes or obesity
- Diabetes complications of the small or large blood vessels
- Diabetic ketoacidosis in the past 24 months or hypoglycemia unawareness
- Smoking now, or quit less than 5 years ago
- Pregnant or nursing women
The registry criteria, word for word
Show all 2 criteriaShow less
Who can take part
- • Male or female ≥21 and ≤50 years old; For persons with T1D: Disease duration ≥ 5 years and HbA1c ≤ 8.5% on multiple daily insulin injection or insulin pump; Body mass index: ≥19 and ≤27 kg/m2 for control and T1D, ≥30 and ≤40 kg/m2 (27.5 to 37.5 for Asian Americans) for obesity and T1D + obesity. BMI is limited to ≤40 kg/m2 (37.5 for Asian Americans) for easier vascular access and cardiac imaging; Stable use of non-insulin medications for over 6 months other than estrogen/progesterone containing medications which must be discontinued at least 3 months prior to the study (intrauterine devices may be continued due to limited systemic absorption)
Who cannot take part
- • Acute or chronic disease other than T1D or obesity; History of microvascular or macrovascular diabetes complications; History of diabetic ketoacidosis in the past 24 months; History of hypoglycemia unawareness; Recently active (>20 min of moderate/high intensity exercise, 2 times/week); Subjects who are smokers or who have quit smoking <5 years; Subjects with hypertriglyceridemia (>400 mg/dl); Current use of vasoactive medications (i.e. calcium channel blockers, angiotensin-converting enzyme or renin inhibitors, angiotensin-receptor blockers, nitrates, alpha- or beta-blockers, or diuretics); Females taking oral contraceptives in the past 3 months; Subjects with a history of significant metabolic, cardiac, cerebrovascular, hematological, pulmonary, gastrointestinal, liver, renal, or endocrine disease or malignancy; Pregnant (as evidenced by positive pregnancy test) or nursing women; Musculoskeletal condition preventing participation in exercise testing or exercise training; History of gastroparesis; Pulse oximetry <90%
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 21 and 50 years old?
Where in United States
- University of VirginiaCharlottesville, United StatesContact: Zhenqi Liu, MDTaking people
About the trial
What the trial wants to find out
The purpose of this study is:
Read full original descriptionShow less
* To see if insulin resistance (how sensitive your muscle tissue is to insulin) is associated with lower cardio fitness in people with Type 1 diabetes compared to healthy controls, before and after a High Intensity Interval Training (HIIT) exercise program. * To see if being overweight and having Type 1 diabetes is associated with lower cardio fitness compared to overweight healthy controls, before and after a HIIT exercise program.
The 4 groups in the trial
- Type 1 diabetes - normal weightExisting treatment, for comparison
Treatment: Exercise training
- Control - normal weightExisting treatment, for comparison
healthy control - normal weight
Treatment: Exercise training
- Overweight controlExisting treatment, for comparison
Overweight, otherwise healthy
Treatment: Exercise training
- Type 1 diabetes - overweightExisting treatment, for comparison
Treatment: Exercise training
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Impact of Obesity on Microvascular Insulin Action and Cardiorespiratory Fitness in Type 1 Diabetes (
- Plain-language title
- How Exercise Training Affects Insulin Response and Fitness in Type 1 Diabetes and OverweightGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT07573228, who can take part
- Record updated
- 7 May 2026