Effects of Short and Long Courses of Intermittent Hypoxic-Hyperoxic Training in Patients With Type 2 Diabetes Including Elderly
Key facts
- Where
- Moscow, RussiaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 50 and 74 years old?
Source: NCT07574333, who can take part
Where in Russia
- National Medical Research Center for Therapy and Preventive MedicineMoscow, RussiaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- National Medical Research Center for Therapy and Preventive Medicine
- Trial code
- NCT07574333
- Record updated
- 7 May 2026
- Original description
This is a single-center randomized controlled trial evaluating the efficacy and safety of short (3 days) versus long (10 days) courses of intermittent hypoxic-hyperoxic training (IHHT) in patients with type 2 diabetes mellitus aged 50-74 years. Participants will be randomized into three groups: 3-day IHHT course (n≥100), 10-day IHHT course (n≥100), or control group receiving gas mixture with constant O2 21% for 10 days (n≥50). The primary outcomes are fasting glucose levels and HbA1c. Secondary outcomes include cardiovascular parameters, quality of life, cognitive function, and biological age.Read full original descriptionShow less
A Single-Center Randomized Clinical Trial With Prospective Follow-up of the Efficacy and Safety of Short and Long Duration Intermittent Hypoxic-Hyperoxic Training in Patients With Type 2 Diabetes Mellitus Including Elderly Patients
This is a single-center randomized controlled trial evaluating the efficacy and safety of short (3 days) versus long (10 days) courses of intermittent hypoxic-hyperoxic training (IHHT) in patients with type 2 diabetes mellitus aged 50-74 years. Participants will be randomized into three groups: 3-day IHHT course (n≥100), 10-day IHHT course (n≥100), or control group receiving gas mixture with constant O2 21% for 10 days (n≥50). The primary outcomes are fasting glucose levels and HbA1c. Secondary outcomes include cardiovascular parameters, quality of life, cognitive function, and biological age.
Inclusion: Age 50-74 years inclusive; Type 2 diabetes mellitus confirmed by medical documentation; Stable therapy for diabetes and other chronic diseases for at least 4 weeks prior to enrollment; Ability to comply with study protocol requirements; Signed informed consent.
Exclusion: Type 1 diabetes mellitus; Acute diabetes complications within 6 months (diabetic ketoacidosis, hyperosmolar hyperglycemic state, lactic acidosis, hypoglycemic coma); Acute or active chronic infections; Angina pectoris functional class III-IV; Uncontrolled grade 3 arterial hypertension (SBP ≥180 and/or DBP ≥110 mmHg); Acute cerebrovascular accident, myocardial infarction, surgical interventions, clinically significant injuries within 6 months; Chronic obstructive pulmonary disease and bronchial asthma; Congenital heart and major vessel abnormalities; Implanted cardiac pacemaker; Mental illness, drug addiction, alcohol dependence; Exacerbation and decompensation of chronic diseases within 1 month ALT and/or AST levels >2-3 times upper limit of normal; Cancer with remission <5 years; Internal carotid artery stenosis >60% and/or symptomatic stenosis 50-99%; Pregnancy; Inability to participate throughout the study period.