The Effect of Lipedema on Knee Osteoarthritis
Key facts
- Where
- Izmir, TürkiyeSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 30 and 65 years old?
Source: NCT07575555, who can take part
Where in Türkiye
- Izmir Democracy UniversityIzmir, TürkiyeContact: Kadir SongürNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Izmir Democracy University
- Trial code
- NCT07575555
- Record updated
- 12 November 2026
- Original description
This study will be one of the few to examine the effect of lipedema on knee osteoarthritis in a comparative manner with a control group within the same osteoarthritis context. Although the relationship between obesity and osteoarthritis has been extensively studied in the literature, the effect of specific adipose tissue pathologies, such as lipedema, on osteoarthritis has not been sufficiently investigated. This study aims to demonstrate the independent effect of lipedema on osteoarthritis, evaluate clinical and ultrasonographic parameters together, and contribute to early diagnosis and targeted rehabilitation strategies.Read full original descriptionShow less
The Effect of Lipedema on Knee Osteoarthritis: A Cross-Sectional Analysis of Clinical Symptoms and Ultrasonographic Findings
This study will be one of the few to examine the effect of lipedema on knee osteoarthritis in a comparative manner with a control group within the same osteoarthritis context. Although the relationship between obesity and osteoarthritis has been extensively studied in the literature, the effect of specific adipose tissue pathologies, such as lipedema, on osteoarthritis has not been sufficiently investigated. This study aims to demonstrate the independent effect of lipedema on osteoarthritis, evaluate clinical and ultrasonographic parameters together, and contribute to early diagnosis and targeted rehabilitation strategies.
Inclusion: All participants (Group 1 + Group 2); Women aged 30-65; With a clinical and radiological diagnosis of knee osteoarthritis; Who agreed to participate in the study; Group 1 (knee osteoarthritis with lipedema):; Patients who meet the Wold criteria for a clinical diagnosis of lipedema; An increase in subcutaneous fat thickness confirmed by ultrasound; Group 2 (knee osteoarthritis without lipedema):; No diagnosis of lipedema; Exclusion of lymphedema and venous diseases.
Exclusion: History of knee surgery; Systemic connective tissue disease; Severe venous insufficiency or lymphedema; History of malignancy; Use of gabapentinoids/SNRIs/SSRIs due to fibromyalgia or psychiatric illness; Severe cognitive impairment or communication problems that would prevent participation in the study; Inflammatory arthritis; Intra-articular injection within the past 6 months; Acute trauma; Pregnancy; Participants who were informed about the study and refused to participate.