NCT07576894Recruiting
Right Ventricular Response to Exercise Among Patients With Chronic Obstructive Pulmonary Disease
Phenotyping Resting and Exertional Right Ventricular Dysfunction Among Patients With Chronic Obstructive Pulmonary Disease
Source: ClinicalTrials.gov · Last updated 8 May 2026
Brief summary (registry, in English)
This study plans to learn more about heart function among individuals with chronic obstructive pulmonary disease (COPD). In particular, the investigators want to understand the different patterns of right ventricular response during rest and moderate- vs high-intensity exercise. By identifying patterns of right ventricular dysfunction, this study will help identify better treatments for patients with COPD in the future.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 4 May 2026
- Start date
- 1 Aug 2025
- Primary completion date
- 1 May 2030
- Lead sponsor
- University of Colorado, Denver
- NCT number
- NCT07576894
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 1 Aug 2025 to the primary completion date, 1 May 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Exacerbation of COPD in the 3 months prior to enrollment
- Change in COPD therapy in the 3 weeks prior to enrollment
Other illness
- Known pulmonary hypertension with mean pulmonary artery pressure \>45 mmHg
- Untreated severe obstructive sleep apnea and/or obesity hypoventilation syndrome
- Active malignancy (other than skin)
- Medical conditions that limit exercise on an upright stationary bicycle (e.g. severe osteoarthritis, imbalance/gait instability, etc.)
- For subset undergoing right heart catheterization, chronic anticoagulation that is unable to be held for the study visit
- For subset undergoing right heart catheterization or exercise training, forced expiratory volume in 1 second of \<20%
- For exercise training with an option for hybrid remote exercise training, any medical conditions which threaten the safety of remote exercise training (e.g. imbalance/gait instability, etc.).
Lab values
- Active/uncontrolled cardiovascular disease (e.g. hypertension with blood pressure \>150/100 despite antihypertensives; coronary artery disease with angina; left ventricular ejection fraction ≤40%; uncontrolled arrhythmia; pulmonic, mitral or aortic valvular abnormality greater than mild in severity; tricuspid regurgitation greater than moderate in severity)
Other
- Requirement of \>6 LPM supplemental oxygen at rest
- Requirement of \>10 LPM supplemental oxygen with exertion
- Volume overload (jugular vascular distension or greater than trace peripheral edema)
- World Health Organization Functional Class IV
- Pregnancy
- Body mass index \<18 or \>35
- Hematocrit \<25% or \>55%
- For exercise training, already engaged in routine exercise training (\>30 minutes at \>3 METs 3 times/week or more)
- For exercise training, inability to complete initial in-person exercise training sessions for approximately 35 minutes 3x/week for 3 weeks (followed by exercise training sessions with an option for hybrid remote/in-person participation)
Who the study is looking for
- COPD (determined by ratio of forced expiratory volume in 1 second to forced vital capacity \[FEV1/FVC\] \<0.7)
- Age \>= 40 years
Age in the registry: 40 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Colorado Anschutz Medical Campus Coordinator of this site? Confirm its status | Aurora | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.