Propranolol and Heart Injury After Breast Cancer Surgery in People With Hypertension or Angina
Tests propranolol for protecting the heart after breast cancer surgery.
Plain-language title generated from the registry record
Registry title: Impact of Propranolol Strategies on Myocardial Injury After Breast Cancer Surgery
Key facts
- Where
- Seoul, South KoreaSee the site
- Phase
- Phase 4
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 20 and 70 years old?
Source: NCT07583134, who can take part
Where in South Korea
- Seoul St. Mary's Hospital, The Catholic University of KoreaSeoul, South KoreaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Chang-Ik Yoon
- Trial code
- NCT07583134
- Record updated
- 15 May 2026
- Original description
This study aims to evaluate the impact of using propranolol, a non-selective beta-blocker, on preventing myocardial injury after non-cardiac surgery (MINS) in breast cancer patients who also have hypertension or angina. Stress from surgery and anesthesia can increase sympathetic activity and inflammation, which may lead to heart stress. This pragmatic clinical trial will compare patients who are prescribed propranolol as part of their routine care with those who are not. Researchers will analyze blood samples and surgical tissues collected during normal treatment to observe changes in heart health and the tumor microenvironment.Read full original descriptionShow less
A Pragmatic Clinical Trial to Evaluate the Impact of Clinical Propranolol Strategies on Myocardial Injury After Non-cardiac Surgery (MINS) in Patients Undergoing Breast Cancer Surgery With Hypertension or Angina
This study aims to evaluate the impact of using propranolol, a non-selective beta-blocker, on preventing myocardial injury after non-cardiac surgery (MINS) in breast cancer patients who also have hypertension or angina. Stress from surgery and anesthesia can increase sympathetic activity and inflammation, which may lead to heart stress. This pragmatic clinical trial will compare patients who are prescribed propranolol as part of their routine care with those who are not. Researchers will analyze blood samples and surgical tissues collected during normal treatment to observe changes in heart health and the tumor microenvironment.
Inclusion: Female patients aged 20 to 70 years; Patients diagnosed with hypertension or angina who require medication; Patients diagnosed with unilateral, resectable primary breast cancer (ICD-10: C50), Stage I-III; ECOG performance status of 0-1; Patients scheduled to receive standard postoperative treatment (including adjuvant radiotherapy; Patients who voluntarily decide to participate and sign the written informed consent form.
Exclusion: Patients who have received β-blockers within 30 days prior to screening; Patients with active infectious diseases, autoimmune diseases (including specific rheumatic diseases), coagulation disorders, or cardiovascular diseases other than hypertension or angina pectoris; Patients with moderate to severe asthma or chronic obstructive pulmonary disease (COPD); Patients with a history of malignancy within the past 5 years; Patients with systolic blood pressure < 100 mmHg or heart rate < 55 beats per minute; Patients with clinically significant hepatic, hematologic, or renal dysfunction, defined as any of the following:; ① ANC <1,500/mm3; Platelets <100,000/mm3; Hb <9 g/dL; AST and ALT > 2.5 x upper limit of normal (ULN) ⑤ Alkaline phosphatase > 2.5 x ULN ⑥ Total bilirubin > 1 x ULN ⑦ Serum creatinine >1.5 x ULN or estimated creatinine clearance < 60 mL/min (as calculated using the method standard for the institution); Patients with distant metastases; Patients who are pregnant or breastfeeding at the time of enrollment; Patients for whom data collection is considered difficult at the discretion of the investigator; Patients who are unable to understand or complete study questionnaires.