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Comparing Two Keyhole Surgery Methods for Lymph Node Checks in Endometrial Cancer

Compares vaginal and abdominal keyhole surgery for sentinel lymph node checks in endometrial cancer.

Key facts

Who runs it
Cukurova University
Where
Adana, TürkiyeSee the site
Trial code
Registry title
Comparison of Sentinel Lymph Node Applications in Endometrial Cancer Cases Performed With Vaginal Natural Orifice Transluminal Endoscopic Surgery (V-NOTES) and Conventional Laparoscopy
Status
Not yet recruiting
People taking part
160 people, planned
Started
19 May 2026
Expected to end
30 Apr 2036
Type of study
Observational
Record updated
20 May 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with early-stage endometrial cancer that has not spread outside the uterus. They will have surgery with sentinel lymph node biopsy, by laparoscopy or by vNOTES (through the vagina).

Age
18 years or older
Sex
Women only
Disease stage
Endometrial cancer confirmed by biopsy, confined to the uterus. No spread to lymph nodes or distant organs on PET/CT or MRI.
Earlier treatment
No earlier radiotherapy to the pelvis.

Main reasons for not taking part

  • Cancer outside the uterus
  • Distant spread (metastasis)
  • Surgery done through an open abdominal cut (laparotomy)
  • Incomplete medical records
  • Earlier radiotherapy to the pelvis

The registry criteria, word for word

Show all 11 criteriaShow less

Who can take part

  • Age ≥18 years
  • Histologically confirmed endometrial cancer on preoperative endometrial biopsy
  • Disease confirmed to be confined to the uterus based on clinical evaluation and imaging
  • No evidence of lymphatic or distant metastasis on positron emission tomography/computed tomography(PET/CT) or magnetic resonance imaging (MRI)
  • Surgical staging with sentinel lymph node biopsy recommended by a multidisciplinary tumor board
  • Surgical treatment performed using either conventional laparoscopy or the vNOTES approach

Who cannot take part

  • Surgery performed via an open (laparotomy) approach
  • History of prior pelvic radiotherapy
  • Presence of extrauterine disease
  • Detection of distant metastasis
  • Incomplete medical records

Where in Türkiye

  • Cukurova UnivercityAdana, TürkiyeContact: Ghanim KhatibNo longer taking part

About the trial

What the trial wants to find out

Endometrial cancer is a common cancer in women, and surgery is usually the first step in treatment. During surgery, doctors often check nearby lymph nodes to see if the cancer has spread. A newer method called sentinel lymph node (SLN) mapping allows doctors to examine only the first few lymph nodes most likely to contain cancer. This can reduce the need for removing many lymph nodes and may lower the risk of complications.

Read full original descriptionShow less

Minimally invasive surgery is commonly performed using small abdominal incisions (laparoscopy). A newer technique, called vaginal natural orifice transluminal endoscopic surgery (vNOTES), allows the surgery to be performed through the vagina without any cuts on the abdomen. This approach may lead to less pain, quicker recovery, and no visible scars.

This study will compare these two surgical methods-laparoscopy and vNOTES-in patients with early-stage endometrial cancer. Researchers will look at how safe and effective each method is, how patients recover after surgery, and how well the sentinel lymph node procedure works with each technique. The study will also examine how quickly surgeons become experienced with the newer vNOTES method.

The goal of this research is to determine whether vNOTES can be a safe and effective alternative to standard laparoscopic surgery, while offering potential benefits for patients.

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

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Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Comparison of Sentinel Lymph Node Applications in Endometrial Cancer Cases Performed With V-NOTES and Conventional Laparoscopy: A Multicenter Prospective Observational Study
Plain-language title
Comparing Two Keyhole Surgery Methods for Lymph Node Checks in Endometrial CancerGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
20 May 2026