Brain imaging to study connections after stroke in the middle cerebral artery
Uses MRI brain scans to map how stroke affects connections in adults.
Plain-language title generated from the registry record
Registry title: Connectomic Alterations Following Acute Ischemic Stroke in the MCA Territory
Key facts
- Where
- New York, United StatesSee the site
Where in United States
- Lenox Hill HospitalNew York, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Northwell Health
- Trial code
- NCT07584681
- Record updated
- 30 October 2026
- Original description
This study seeks to use safe, powerful, non-invasive computing tools, including machine learning and advanced neuroimaging analysis, to better understand how stroke affects the brain's network of connections. Using structural MRI, including diffusion-weighted imaging, this study will generate a detailed map of brain pathways to evaluate how strokes in the middle cerebral artery (MCA) territory disrupt the brain's structural networks. In the future, this approach may help physicians better predict recovery, monitor neuroplasticity, and guide rehabilitation decisions after stroke.Read full original descriptionShow less
Connectomic Alterations Following Acute Ischemic Stroke in the Middle Cerebral Artery Territory: A Pilot Study of Prognostic Value and Structural Disruption
This study seeks to use safe, powerful, non-invasive computing tools, including machine learning and advanced neuroimaging analysis, to better understand how stroke affects the brain's network of connections. Using structural MRI, including diffusion-weighted imaging, this study will generate a detailed map of brain pathways to evaluate how strokes in the middle cerebral artery (MCA) territory disrupt the brain's structural networks. In the future, this approach may help physicians better predict recovery, monitor neuroplasticity, and guide rehabilitation decisions after stroke.
Inclusion: Age > 18 years; Diagnosis of acute ischemic stroke with confirmed occlusion of the M1 or more distal MCA territory; Received reperfusion therapy via mechanical thrombectomy or IV thrombolytics(Tenecteplase, or Alteplase); Presence of a motor deficit on initial clinical exam (e.g., NIHSS > 0) and on immediate post-intervention exam; Patients or health-care proxy must be able to provide informed consent; Must be able to undergo sequential MRI at Lenox Hill Hospital, including resting-state fMRI (rs-fMRI) and diffusion MRI (dMRI) for, respectively, functional, and structural connectomic analyses.
Exclusion: Known neurodegenerative disease or prior stroke affecting motor pathways; Inability to undergo MRI due to cardiac pacemaker, claustrophobia, and metal implants that cannot be removed prior to MRI; Pre-stroke Modified Rankin Scale score ≥ 3; Age < 17 years; Pregnancy. Because of potential risk of serial MRI to fetus, women of child-bearing age require a pregnancy test at screening and agree to contraceptive practices during the study; Large vessel occlusions proximal to M1 (e.g., ICA), completed M1 occlusions; Poor image quality or incomplete imaging datasets.